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  • JGP 100th Anniversary
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  • Functional anatomy of CFTR
  • Stac proteins interact directly with CaV1.1
  • Effects of retinoid cycle inhibition on cone vision
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Newest Articles

  • Full and partial agonists evoke distinct structural changes in opening the muscle acetylcholine receptor channel
    Different agonists evoke distinct structural changes

    Different agonists activate the muscle AChR with different efficacies. Mukhtasimova and Sine show that oxidative cross-linking of proximal residues alters the ability of some agonists but not others to open the AChR channel. The findings show that, in opening the channel, agonists with differing efficacy elicit distinct structural changes.

    Nuriya Mukhtasimova ... Steven M. Sine
    Research Article | April 21, 2018
  • ­­Mitochondrial ATP synthase dimers spontaneously associate due to a long-range membrane-induced force­
    Membrane force drives ATP synthase dimers to form rows

    Rows of ATP synthase dimers define the cristae morphology of the inner mitochondrial membrane. Anselmi et al. use molecular simulations to show that the formation of these rows is spontaneous and driven by an attractive force induced by the membrane, not direct protein–protein interactions.

    Claudio Anselmi ... José D. Faraldo-Gómez
    Communication | April 11, 2018
  • The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels
    Altered fast and slow gating elicited by Cx26G12R

    Mutations in connexin 26 hemichannels that cause syndromic deafness have a gain-of-function phenotype that is poorly understood. García et al. show that one such mutation impairs fast and slow gating in these hemichannels because of an interaction between the N terminus and intracellular loop.

    Isaac E. García ... Carlos González
    Research Article | April 11, 2018
  • Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid
    Tuning of a potassium-channel modulator

    Dehydroabietic acid was recently shown to open voltage-gated potassium channels. Silverå Ejneby et al. show that its effect peaks when the carboxyl-group charge and hydrophobic anchor are separated by three atoms and use this rule to design molecules that open the human Kv7.2/7.3 potassium channel.

    Malin Silverå Ejneby ... Fredrik Elinder
    Research Article | April 06, 2018
  • Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels
    Intrinsic ligand regulates KCNH channels

    KCNH potassium channels possess an intrinsic ligand in their cyclic nucleotide-binding homology domain, located at the N- and C-terminal domain interface. Dai et al. show that this intrinsic ligand regulates voltage-dependent potentiation via a rearrangement between the ligand and its binding site.

    Gucan Dai ... William N. Zagotta
    Research Article | March 22, 2018
  • Endocytosis sustains release at photoreceptor ribbon synapses by restoring fusion competence
    Endocytosis restores release at ribbon synapses

    In addition to recycling vesicles, synaptic endocytosis restores release site competence after exocytosis. Wen et al. show that endocytosis is essential for subsequent fusion but not docking of vesicles at photoreceptor ribbon synapses and for maintaining release at modest frequencies.

    Xiangyi Wen ... Wallace B. Thoreson
    Research Article | March 19, 2018
  • Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function
    Effects of retinoid cycle inhibition on cone vision

    RPE65 is a retinoid isomerase essential for rod function, but its contribution to cone vision is enigmatic. Using selective RPE65 inhibitors, Kiser et al. demonstrate that cone function depends only partially on continuous RPE65 activity, providing support for cone-specific regeneration mechanisms.

    Philip D. Kiser ... Krzysztof Palczewski
    Research Article | March 02, 2018
All Newest Articles
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The Journal of General Physiology: 150 (4)

Current Issue

April 2, 2018
Volume 150, No. 4

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Reviews & Opinions

  • The ins and outs of vesicular monoamine transporters

    Yaffe et al. review structure-guided studies that have provided insight into the mechanism of proton-monoamine antiport by VMATs.

    Dana Yaffe ... Shimon Schuldiner Viewpoint | April 17, 2018
  • Structural mechanisms of CFTR function and dysfunction

    Hwang et al. integrate new structural insights with prior functional studies to reveal the functional anatomy of CFTR chloride channels.

    Tzyh-Chang Hwang ... Samantha Destefano Review | March 26, 2018
  • How an intrinsic ligand tunes the activity of a potassium channel

    Khoo and Pless examine new work that provides mechanistic insight into the role of the intrinsic ligand in KCNH ion channels.​

    Keith K. Khoo ... Stephan A. Pless Commentary | March 22, 2018

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