Newest Articles
Recovery from acidosis in HypoKPPHypokalemic periodic paralysis causes episodes of muscle weakness. Mi et al. investigate the rest-induced weakness that occurs after vigorous exercise and find that acidosis, as occurs with exercise, leads to accumulation of myoplasmic Cl−, which favors a depolarized resting potential when pH returns to normal.
Ankyrin chains act as biological springs to open the NOMPC channelThe mechanosensitive channel NOMPC comprises a pore-forming transmembrane domain plus four helical ankyrin repeats that extend into the cytoplasm. Using computational approaches, Argudo et al. show that compression of the ankyrin chains imparts a rotational torque on a putative gating element.
Simulations help interpret BetP spectroscopic dataUse of spectroscopic techniques to complement structural data and enhance mechanistic understanding of membrane proteins is often complicated by experimental discrepancies. Leone et al. address this challenge by applying an advanced simulation methodology to the interpretation of spectroscopic data for the transporter protein BetP.
Organization of the skeletal muscle couplonRyanodine receptors in the sarcoplasmic reticulum and voltage-gated Ca2+ channels on T tubules or the cell membrane coassemble into structures called couplons. Ríos et al. use quantitative simulations to test a simple hypothesis on the organization of couplons and derive functional implications of this arrangement.
Biosensor for optical subcellular pharmacokineticsNicotine permeates into the endoplasmic reticulum (ER) where it begins an “inside-out” pathway that leads to addiction. Shivange et al. develop genetically encoded nicotine biosensors and show that nicotine and varenicline equilibrate in the ER within seconds of extracellular application.
Novel ASCT2 inhibitorsASCT2 is a transporter that exchanges neutral amino acids such as glutamine across the cell membrane, an essential process for rapidly growing cells, including cancerous ones. Ndaru et al. report the synthesis and characterization of a novel class of inhibitors useful for studying this transporter.
Regulation of myofilament function by sMyBP-CMyosin binding protein C (MyBP-C) is thought to regulate the contraction of skeletal muscle. Robinett et al. show that phosphorylation of slow skeletal MyBP-C modulates contraction by recruiting cross-bridges, modifying cross-bridge kinetics, and altering internal drag forces in the C-zone.
Current Issue
February 4, 2019
Volume 151, No. 2
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Reviews & Opinions
- Getting into the thick (and thin) of it
Irving and Craig reflect on new work showing that thick filament activation involves myosin motors returning to their OFF state during diastole.
- Unraveling the mechanisms of calcium-dependent secretion
Anantharam and Kreutzberger describe the reductionist approaches that have begun to unveil the mechanistic basis of secretion.
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A special issue of JGP celebrates the 2018 Symposium of the Society of General Physiologists, where diversity and world-class science went hand in hand.