Newest Articles
Conduction of PIP2-bound GIRK2 in the absence of GβγG-protein–gated inwardly rectifying potassium channels are important mediators of inhibitory neurotransmission. Based on microsecond-scale molecular dynamics simulations, Bernsteiner et al. propose novel gating details that may enable K+ flux via a direct knock-on mechanism.
A model for ligand sensitivity in a cyclic nucleotide–gated ion channelHCN channel opening is facilitated by cyclic nucleotides, but what determines the sensitivity of these channels to cAMP or cGMP is unclear. Ng et al. propose that ligand sensitivity depends on negative cooperativity and the asymmetric effects of ligand binding on channel structure and pore opening.
Triple arginines determine pentamerization and conductanceSerotonin type 3A receptors are homopentameric ligand-gated ion channels that are thought to assemble via interactions involving the subunits’ extracellular and transmembrane domains. Pandhare et al. reveal that channel assembly is also determined by three arginine residues in the receptor’s intracellular domain.
Switching off 10S myosin II activityThree-dimensional electron microscopy reveals that myosin II molecules are kept inactive by intramolecular interactions between the heads and the tail that inhibit actin binding, ATPase activity, filament formation, and phosphorylation. This suggests how myosin can be stored in cells with minimal energy consumption.
Stochastic model of ion channel clusteringIon channels are often found in dense clusters within the plasma membranes of excitable cells. Based on experimental measurements of a wide range of channels in various cell types, Sato et al. propose that channel clusters form stochastically and that their size is regulated by a common feedback mechanism.
Dysfunction and troponin I phosphorylationCardiac troponin I Ser44 is a downstream target for protein kinase C. The current studies show heightened phosphorylation develops during contractile dysfunction in failing human myocardium and in rat models of pressure overload and aging with contractile dysfunction.
Regulation of somatostatin secretionThe regulation of somatostatin secretion from islet δ-cells remains obscure. Denwood et al. show that glucose stimulates somatostatin secretion through effects on both δ-cell electrical activity and cAMP-dependent intracellular Ca2+ release.
Current Issue
September 2, 2019
Volume 151, No. 9
Submit your Research
Reviews & Opinions
- Progress on the representation of women in JGP
One year after implementing a policy to include at least one female reviewer for each manuscript, we review the effectiveness of our strategy.
- Measurement of intracellular ion activity in skeletal muscle fibers: four microelectrodes or no deal
Allard reviews a new powerful method allowing measurement of intracellular ion activity in isolated skeletal muscle fibers.
Most Read
Advertisement
JGP study uses MD simulations to investigate the gating and conductance of the inwardly rectifying potassium channel GIRK2.