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Newest Articles
AMPA receptor modulation by γ8Using single-channel recordings and single-molecule FRET, Carrillo et al. show that resensitization of α-amino-5-methyl-3-hydroxy-4-isoxazole propionate receptors by the regulatory protein γ8 is characterized by transitions to high conductance levels associated with tighter conformational coupling similar to those seen in the presence of cyclothiazide.
Kir channel gating and conductanceThis paper presents the crystal structure of a forced open inward rectifier Kir2.2 channel. Molecular dynamics reveals the details of ion permeation through the open channel.
Lattice/fiber type correlation in skeletal muscleMa et al. studied the 3-D arrangement of thick filaments in skeletal muscle by x-ray diffraction and electron microscopy and found a correlation between thick filament lattice type (simple or superlattice) and fiber type (fast/slow). This suggests that lattice organization contributes to muscle functional properties.
Frequency-dependent effects of prestin’s kinetics and loadCochlear amplification is mediated by the outer hair cell of the organ of Corti. Santos-Sacchi et al. reveal that the cell possesses a voltage-dependent motile frequency response that differs from that of its voltage sensor/effector, the electromotile protein prestin, implying variable coupling between the two.
Exocytosis of MMP-9 in cancer cellsThis paper describes the dynamics of proteins and lipids during exocytosis of MMP-9 from cancer cells in real time using fluorescence microscopy. Stephens et al. find that core exocytic proteins, accessory proteins, and lipids are involved at sites of secretory vesicle fusion.
KtrB’s channel profileKtrAB is a bacterial ion channel with a noncanonical selectivity filter. Consequently, it was assumed to be rather unselective for monovalent cations. Mikušević et al. show that in the presence of Na+, KtrAB very selectively translocates K+, which results from a high binding affinity and facilitated K+ gating.
Nramp M2+:H+ cotransport and uniport mechanismsAn Nramp transition metal transporter performs metal uniport, proton uniport, and proton–metal cotransport. Transmembrane voltage and pH gradients govern the rates of these processes, largely through a conserved salt-bridge network in the transmembrane scaffold of the transporter’s LeuT fold.
Current Issue
November 4, 2019
Volume 151, No. 11
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Reviews & Opinions
- Determining the dynamics of cancer cell secretion
JGP study describes the spatiotemporal dynamics of proteins and lipids involved in the exocytosis of the matrix metalloproteinase MMP-9 from breast cancer cells.
- Mammalian muscle fibers may be simple as well as slow
Squire and Luther consider new evidence for a simple lattice structure in mammalian skeletal muscle.
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Moss considers recent work describing the effect of low temperature on force development in skeletal muscle.