Neuronal plasticity in adulthood is important for adaptation to different environments. Frolov et al. show that rearing mature Periplaneta americana in prolonged light or dark leads to distinct changes in photoreceptor responses, suggesting remodeling of the light-sensitive membrane.

C-type inactivation in K⁺ channels is thought to be a result of constriction of the selectivity filter. By using MD simulations, Li et al. show that rapid constriction occurs within 1–2 s when the intracellular activation gate is fully open, but not when the gate is closed or partially open.

Singlet oxygen modifies several different proteins within cells. Idikuda et al. show that, in the case of the sea urchin hyperpolarization-activated cyclic nucleotide–gated channel, a histidine residue in S6 is essential for the abolition of voltage-dependent inactivation by singlet oxygen.