Newest Articles
The transport cycle of GlyT1 and GlyT2Erdem et al. compare the kinetics of the SLC6 family glycine transporters GlyT1 and GlyT2. Though the two transporters are rate-limited by distinct reaction steps, they both display high transport capacity, with the kinetics of GlyT1 sufficient to supply extracellular glycine to the NMDA receptor.
Myosin orientation in muscleHigh-resolution structural information is invaluable for understanding muscle function. Savich et al. use bifunctional spin labeling to determine the orientation of the myosin lever arm in muscle fibers at high resolution under ambient conditions, augmenting previous insights obtained from fluorescence and EM.
PI3K regulation of heart rate and IFHeart rate is set by the specialized tissue of the sinoatrial node. Lin et al. demonstrate a novel role for phosphoinositide 3-kinase in regulating cardiac pacemaking currents independently of the autonomic nervous system, a finding with relevance for diabetes, heart disease, and cancer.
Phosphoinositide dependence of TPC3Among the three two-pore channels (TPCs), TPC1 and TPC2 are selectively activated by PI(3,5)P2, while TPC3 has been considered not to respond to any PIP2s. Shimomura and Kubo find that TPC3 responds to both PI(3,5)P2 and PI(3,4)P2, but not to PI(4,5)P2.
Binding sites for CFTR potentiatorsIdentification of the binding sites for small molecules that alleviate gating defects in CFTR would assist rational drug design for the treatment of cystic fibrosis. Yeh et al. identify two potential binding sites for prototypical CFTR potentiators at the interface of CFTR’s two transmembrane domains.
P2X receptor ligand recognition and discernmentP2X receptors (P2XRs) are ligand-gated cation channels involved in pain and inflammation. Gasparri et al. show that the backbone carbonyl atoms of amino acid residue Thr184 are involved in ligand discrimination, while those of Lys69 contribute mostly to ligand recognition by rat P2X2Rs.
RYR3 ablation affects EOM functionExtraocular muscles are specialized skeletal muscles expressing a particular set of proteins involved in calcium homeostasis, including RYR3. Eckhardt et al. investigate extraocular muscle function in ryr3−/− mice and show that ablation of RYR3 significantly impacts vision.
Current Issue
July 1, 2019
Volume 151, No. 7
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Reviews & Opinions
- A primer on resolving the nanoscale structure of the plasma membrane with light and electron microscopy
Taraska reviews the imaging methods that are being used to understand the structure of the plasma membrane at the molecular level.
- With PIPs, you get ZIPs and blips
Senning discusses new research on the regulation of two-pore sodium channels by different phosphoinositide phosphates.
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Andersen et al. commemorate the life of the eminent physiologist, David Gadsby.