Newest Articles
Mechanisms for CICR terminationCannell and Kong discuss the different termination mechanisms proposed for CICR in cardiac myocytes.
Control of RyR2 by SR luminal Ca2+Jones et al. propose that SR luminal Ca2+ regulates RyR2 activity via a luminal Ca2+ sensor distinct from the cytosolic Ca2+ sensor.
Luminal Ca regulation of cardiac refractorinessGyörke et al. discuss the role of sarcoplasmic reticulum Ca2+ in cardiac refractoriness and pathological implications.
Atrial excitation-contraction couplingBlatter discusses the initiation and spread of Ca release, Ca store depletion, and release termination in atrial myocytes.
Cardiac excitation–contraction couplingFive groups of experts unravel the complex modulation of a function crucial for the beating heart.
SR Ca2+ release regulationSobie et al. highlight unresolved issues concerning the regulation of sarcoplasmic reticulum calcium release in cardiac myocytes.
Mechanisms of Na+ channel regulation by β1 and β3Voltage-gated NaV channels are modulated by two different noncovalent accessory subunits: β1 and β3. Zhu et al. present data showing that β1 and β3 cause distinct effects on channel gating because they interact with NaV channels at different locations. β3 regulates the voltage sensor in domain III, whereas β1 regulates the one in domain IV.
Current Issue
August 7, 2017
Volume 149, No. 8
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Reviews & Opinions
- Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2+
Jones et al. propose that SR luminal Ca2+ regulates RyR2 activity via a luminal Ca2+ sensor distinct from the cytosolic Ca2+ sensor.
- The role of luminal Ca regulation in Ca signaling refractoriness and cardiac arrhythmogenesis
Györke et al. discuss the role of sarcoplasmic reticulum Ca2+ in cardiac refractoriness and pathological implications.
Cannell and Kong discuss the different termination mechanisms proposed for CICR in cardiac myocytes.