Newest Articles
Age-associated pacemaker function deteriorationPacemaker function deteriorates in advanced age. Behar and Yaniv show that both intracellular and membrane mechanisms are responsible for age-associated pacemaker function deterioration and explain why the maximal beating rate is restored as a result of changes in sensitivity of HCN4 to cAMP and phospholamban to PKA.
Coarse-grained simulations of Phe-Gly nucleoporinsThe phenylalanine-glycine–repeat nucleoporins are essential for transport through the nuclear pore complex. Pulupa et al. observe reptation of these nucleoporins on a physiological timescale in coarse-grained computational simulations.
Slow fusion pore creates a unique reaction chamberA lumenal secretory granule protein can slow fusion pore dilation and thus its own discharge. Bohannon et al. demonstrate another outcome: the creation of a nanoscale chemical reaction chamber for granule contents in which the pH is suddenly neutralized upon fusion.
Control of RyR2 by SR luminal Ca2+Jones et al. propose that SR luminal Ca2+ regulates RyR2 activity via a luminal Ca2+ sensor distinct from the cytosolic Ca2+ sensor.
Mechanisms for CICR terminationCannell and Kong discuss the different termination mechanisms proposed for CICR in cardiac myocytes.
Luminal Ca regulation of cardiac refractorinessGyörke et al. discuss the role of sarcoplasmic reticulum Ca2+ in cardiac refractoriness and pathological implications.
Atrial excitation-contraction couplingBlatter discusses the initiation and spread of Ca release, Ca store depletion, and release termination in atrial myocytes.
Current Issue
September 4, 2017
Volume 149, No. 9
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Reviews & Opinions
- The enduring legacy of the “constant-field equation” in membrane ion transport
Alvarez and Latorre describe the long-lasting contribution of Goldman’s equation to our understanding of membrane transport.
- 100 years and counting: JGP celebrates its centenary
As JGP approaches its 100th year, dissemination of science is more important than ever.
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JGP hosts key papers that shaped the epithelial transport field.