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The Journal of General Physiology, Vol 108, 277-293, Copyright © 1996 by The Rockefeller University Press
ARTICLES |
DL Campbell, JS Stamler and HC Strauss
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA.
The effects of NO-related activity and cellular thiol redox state on basal L-type calcium current, ICa,L, in ferret right ventricular myocytes were studied using the patch clamp technique. SIN-1, which generates both NO. and O2-, either inhibited or stimulated ICa,L. In the presence of superoxide dismutase only inhibition was seen. 8-Br- cGMP also inhibited ICa,L, suggesting that the NO inhibition is cGMP- dependent. On the other hand, S-nitrosothiols (RSNOs), which donate NO+, stimulated ICa,L. RSNO effects were not dependent upon cell permeability, modulation of SR Ca2+ release, activation of kinases, inhibition of phosphatases, or alterations in cGMP levels. Similar activation of ICa,L by thiol oxidants, and reversal by thiol reductants, identifies an allosteric thiol-containing "redox switch" on the L-type calcium channel subunit complex by which NO/O2- and NO+ transfer can exert effects opposite to those produced by NO. In sum, our results suggest that: (a) both indirect (cGMP-dependent) and direct (S-nitrosylation/oxidation) regulation of ventricular ICa,L, and (b) sarcolemma thiol redox state may be an important determinant of ICa,L activity.
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C.-M. L. Tseng, M. A. Tabrizi-Fard, and H.-L. Fung Differential Sensitivity among Nitric Oxide Donors toward ODQ-Mediated Inhibition of Vascular Relaxation J. Pharmacol. Exp. Ther., February 1, 2000; 292(2): 737 - 742. [Abstract] [Full Text]
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H.-T. Ma, C. J. Favre, R. L. Patterson, M. R. Stone, and D. L. Gill Ca2+ Entry Activated by S-Nitrosylation. RELATIONSHIP TO STORE-OPERATED Ca2+ ENTRY J. Biol. Chem., December 10, 1999; 274(50): 35318 - 35324. [Abstract] [Full Text] [PDF]
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J.-M. Chesnais, R. Fischmeister, and P.-F. Mery Peroxynitrite is a positive inotropic agent in atrial and ventricular fibres of the frog heart J. Physiol., December 1, 1999; 521(2): 375 - 388. [Abstract] [Full Text] [PDF]
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 M. Taglialatela, A. Pannaccione, S. Iossa, P. Castaldo, and L. Annunziato Modulation of the K+ Channels Encoded by the Human Ether-a-Gogo-Related Gene-1 (hERG1) by Nitric Oxide Mol. Pharmacol., December 1, 1999; 56(6): 1298 - 1308. [Abstract] [Full Text]
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M. V. Brahmajothi and D. L. Campbell Heterogeneous Basal Expression of Nitric Oxide Synthase and Superoxide Dismutase Isoforms in Mammalian Heart : Implications for Mechanisms Governing Indirect and Direct Nitric Oxide-Related Effects Circ. Res., October 1, 1999; 85(7): 575 - 587. [Abstract] [Full Text] [PDF]
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M. A. Harrington, K. L. Gunderson, and R. R. Kopito Redox Reagents and Divalent Cations Alter the Kinetics of Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating J. Biol. Chem., September 24, 1999; 274(39): 27536 - 27544. [Abstract] [Full Text] [PDF]
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W. J Paulus and A. M Shah NO and cardiac diastolic function Cardiovasc Res, August 15, 1999; 43(3): 595 - 606. [Full Text] [PDF]
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J.-L. Balligand Regulation of cardiac {beta}-adrenergic response by nitric oxide Cardiovasc Res, August 15, 1999; 43(3): 607 - 620. [Full Text] [PDF]
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J.-M. Chesnais, R. Fischmeister, and P.-F. Mery Positive and negative inotropic effects of NO donors in atrial and ventricular fibres of the frog heart J. Physiol., July 15, 1999; 518(2): 449 - 461. [Abstract] [Full Text] [PDF]
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E. Carmeliet Cardiac Ionic Currents and Acute Ischemia: From Channels to Arrhythmias Physiol Rev, July 1, 1999; 79(3): 917 - 1017. [Abstract] [Full Text] [PDF]
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B. A. Summers, J. L. Overholt, and N. R. Prabhakar Nitric Oxide Inhibits L-Type Ca2+ Current in Glomus Cells of the Rabbit Carotid Body Via a cGMP-Independent Mechanism J Neurophysiol, April 1, 1999; 81(4): 1449 - 1457. [Abstract] [Full Text] [PDF]
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 M. V. Brahmajothi, D. L. Campbell, R. L. Rasmusson, M. J. Morales, J. S. Trimmer, J. M. Nerbonne, and H. C. Strauss Distinct Transient Outward Potassium Current (Ito) Phenotypes and Distribution of Fast-inactivating Potassium Channel Alpha Subunits in Ferret Left Ventricular Myocytes J. Gen. Physiol., April 1, 1999; 113(4): 581 - 600. [Abstract] [Full Text] [PDF]
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 G. J. JI, B. K. FLEISCHMANN, W. BLOCH, M. FEELISCH, C. ANDRESSEN, K. ADDICKS, and J. HESCHELER Regulation of the L-type Ca2+ channel during cardiomyogenesis: switch from NO to adenylyl cyclase-mediated inhibition FASEB J, February 1, 1999; 13(2): 313 - 324. [Abstract] [Full Text]
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I M Fearon, A C V Palmer, A J Balmforth, S G Ball, G Varadi, and C Peers Modulation of recombinant human cardiac L-type Ca2+ channel {alpha}1C subunits by redox agents and hypoxia J. Physiol., February 1, 1999; 514(3): 629 - 637. [Abstract] [Full Text] [PDF]
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K. Y. Xu, D. L. Huso, T. M. Dawson, D. S. Bredt, and L. C. Becker Nitric oxide synthase in cardiac sarcoplasmic reticulum PNAS, January 19, 1999; 96(2): 657 - 662. [Abstract] [Full Text] [PDF]
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C. J. Favre, C. A. Ufret-Vincenty, M. R. Stone, H.-T. Ma, and D. L. Gill Ca2+ Pool Emptying Stimulates Ca2+ Entry Activated by S-Nitrosylation J. Biol. Chem., November 20, 1998; 273(47): 30855 - 30858. [Abstract] [Full Text] [PDF]
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J. Ren, M. F. Walsh, M. Hamaty, J. R. Sowers, and R. A. Brown Altered inotropic response to IGF-I in diabetic rat heart: influence of intracellular Ca2+ and NO Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H823 - H830. [Abstract] [Full Text] [PDF]
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M. Lu and W.-H. Wang Reaction of nitric oxide with superoxide inhibits basolateral K+ channels in the rat CCD Am J Physiol Cell Physiol, July 1, 1998; 275(1): C309 - C316. [Abstract] [Full Text] [PDF]
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N. Gaudiot, A.-M. Jaubert, E. Charbonnier, D. Sabourault, D. Lacasa, Y. Giudicelli, and C. Ribiere Modulation of White Adipose Tissue Lipolysis by Nitric Oxide J. Biol. Chem., May 29, 1998; 273(22): 13475 - 13481. [Abstract] [Full Text] [PDF]
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X. Han, I. Kubota, O. Feron, D. J. Opel, M. A. Arstall, Y.-Y. Zhao, P. Huang, M. C. Fishman, T. Michel, and R. A. Kelly Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of endothelial nitric oxide synthase PNAS, May 26, 1998; 95(11): 6510 - 6515. [Abstract] [Full Text] [PDF]
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Y.-W. Xie, P. M. Kaminski, and M. S. Wolin Inhibition of Rat Cardiac Muscle Contraction and Mitochondrial Respiration by Endogenous Peroxynitrite Formation During Posthypoxic Reoxygenation Circ. Res., May 4, 1998; 82(8): 891 - 897. [Abstract] [Full Text] [PDF]
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B. L. Tepperman, T. D. Abrahamson, and B. D. Soper The Role of Cyclic Guanylate Monophosphate in Nitric Oxide-Induced Injury to Rat Small Intestinal Epithelial Cells J. Pharmacol. Exp. Ther., March 1, 1998; 284(3): 929 - 933. [Abstract] [Full Text]
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R. Ferrari Tumor necrosis factor in CHF: a double facet cytokine Cardiovasc Res, March 1, 1998; 37(3): 554 - 559. [Full Text] [PDF]
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 L. Xu, J. P. Eu, G. Meissner, and J. S. Stamler Activation of the Cardiac Calcium Release Channel (Ryanodine Receptor) by Poly-S-Nitrosylation Science, January 9, 1998; 279(5348): 234 - 237. [Abstract] [Full Text]
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Y. G. Wang, C. E. Rechenmacher, and S. L. Lipsius Nitric Oxide Signaling Mediates Stimulation of L-Type Ca2+ Current Elicited by Withdrawal of Acetylcholine in Cat Atrial Myocytes J. Gen. Physiol., January 1, 1998; 111(1): 113 - 125. [Abstract] [Full Text] [PDF]
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