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© The Rockefeller University Press, 0022-1295/1997//169/ $5.00
Journal of General Physiology, Volume 109, Number 2, 1997

Article

Dihydropyridine Action on Voltage-dependent Potassium Channels Expressed in Xenopus Oocytes

Vladimir Avdonin, Erwin F. Shibata, and Toshinori Hoshi

From the Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242

Dihydropyridines (DHPs) are well known for their effects on L-type voltage-dependent Ca2+ channels. However, these drugs also affect other voltage-dependent ion channels, including Shaker K+ channels. We examined the effects of DHPs on the Shaker K+ channels expressed in Xenopus oocytes. Intracellular applications of DHPs quickly and reversibly induced apparent inactivation in the Shaker K+ mutant channels with disrupted N- and C-type inactivation. We found that DHPs interact with the open state of the channel as evidenced by the decreased mean open time. The DHPs effects are voltage-dependent, becoming more effective with hyperpolarization. A model which involves binding of two DHP molecules to the channel is consistent with the results obtained in our experiments.

Key Words: potassium channels • dihydropyridines

Address correspondence to Toshinori Hoshi, Department of Physiology and Biophysics, The University of Iowa, Bowen 5660, Iowa City, IA 52242. Fax: 319-335-7330; E-mail: Toshinori-Hoshi{at}uiowa.edu


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