The Journal of General Physiology
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The Journal of General Physiology, Vol 13, 133-143, Copyright © 1929 by The Rockefeller University Press

ARTICLE

PROTEIN COAGULATION AND ITS REVERSAL

THE REVERSAL OF THE COAGULATION OF HEMOGLOBIN



A. E. Mirsky 1 and M. L. Anson 1

1 From the Hospital of The Rockefeller Institute for Medical Research, New York, N. Y., and the Laboratories of The Rockefeller Institute for Medical Research, Princeton, N. J.

1. The preparation from completely coagulated hemoglobin of crystalline soluble hemoglobin is described.

2. This soluble hemoglobin by all the tests tried has been indistinguishable from normal native hemoglobin which has never been coagulated.

3. The coagulation of hemoglobin is probably reversible.

4. Since hemoglobin is a typical coagulable protein, protein coagulation in general is probably reversible.

 Accepted on June 27, 1929


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