The Journal of General Physiology
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The Journal of General Physiology, Vol 18, 813-819, Copyright © 1935 by The Rockefeller University Press

ARTICLE

STUDIES ON BLOOD COAGULATION

IV. THE NATURE OF THE CLOTTING DEFICIENCY IN HEMOPHILIA



Harry Eagle 1

1 From the Department of Bacteriology, School of Medicine, University of Pennsylvania, Philadelphia, and the Department of Physical Chemistry in the Laboratories of Physiology, The Harvard Medical School, Boston

Despite their reported stability, the platelets of hemophilic blood function normally. The prothrombin content of such plasma is also normal. Confirming the findings of Addis, the delayed coagulation observed in hemophilic blood is due to an unexplained retarded activation of prothrombin to thrombin. The addition of an excess of platelets, whether normal, hemophilic, or animal in origin, accelerates thrombin production and makes hemophilic blood clot normally; but cephalin, despite the fact that it accelerates thrombin production in normal plasma, is unexplainedly ineffective when added to hemophilic plasma.

Accepted on January 4, 1935


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