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The Journal of General Physiology, Vol 27, 37-60, Copyright © 1943 by The Rockefeller University Press

ARTICLE

POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES

David E. Goldman 1

1 From the Department of Physiology, College of Physicians and Surgeons, Columbia University, New York

Impedance and potential measurements have been made on a number of artificial membranes. Impedance changes were determined as functions of current and of the composition of the environmental solutions. It was shown that rectification is present in asymmetrical systems and that it increases with the membrane potential. The behavior in pairs of solutions of the same salt at different concentrations has formed the basis for the studies although a few experiments with different salts at the same concentrations gave results consistent with the conclusions drawn.

A theoretical picture has been presented based on the use of the general kinetic equations for ion motion under the influence of diffusion and electrical forces and on a consideration of possible membrane structures. The equations have been solved for two very simple cases; one based on the assumption of microscopic electroneutrality, and the other on the assumption of a constant electric field. The latter was found to give better results than the former in interpreting the data on potentials and rectification, showing agreement, however, of the right order of magnitude only. Although the indications are that a careful treatment of boundary conditions may result in better agreement with experiment, no attempt has been made to carry this through since the data now available are not sufficiently complete or reproducible. Applications of the second theoretical case to the squid giant axon have been made showing qualitative agreement with the rectification properties and very good agreement with the membrane potential data.

 Submitted on April 21, 1943


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J Neurophysiol, February 1, 1997; 77(2): 702 - 708.
[Abstract] [Full Text] [PDF]

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 JGPHome page
J. C. Freedman and T. S. Novak
Electrodiffusion, Barrier, and Gating Analysis of DIDS-insensitive Chloride Conductance in Human Red Blood Cells Treated with Valinomycin or Gramicidin
J. Gen. Physiol., February 1, 1997; 109(2): 201 - 216.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
S. A. N. Goldstein, L. A. Price, D. N. Rosenthal, and M. H. Pausch
ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae
PNAS, November 12, 1996; 93(23): 13256 - 13261.
[Abstract] [Full Text] [PDF]

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A. Etter, D. F. Cully, J. M. Schaeffer, K. K. Liu, and J. P. Arena
An Amino Acid Substitution in the Pore Region of a Glutamate-gated Chloride Channel Enables the Coupling of Ligand Binding to Channel Gating
J. Biol. Chem., July 5, 1996; 271(27): 16035 - 16039.
[Abstract] [Full Text] [PDF]

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G. F. Wilson, F. C. Richardson, T. E. Fisher, B. M. Olivera, and L. K. Kaczmarek
Identification and Characterization of a Ca2+-Sensitive Nonspecific Cation Channel Underlying Prolonged Repetitive Firing in Aplysia Neurons
J. Neurosci., June 1, 1996; 16(11): 3661 - 3671.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
M. L. Collier, P. C. Levesque, J. L. Kenyon, and J. R. Hume
Unitary Cl- Channels Activated by Cytoplasmic Ca2+ in Canine Ventricular Myocytes
Circ. Res., May 1, 1996; 78(5): 936 - 944.
[Abstract] [Full Text]

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 Arch SurgHome page
D. A. Goller, W. F. Weidema, and R. J. Davies
Transmural Electrical Potential Difference as an Early Marker in Colon Cancer
Arch Surg, March 1, 1986; 121(3): 345 - 350.
[Abstract] [PDF]

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 Toxicol Ind HealthHome page
N. Sperelakis, P. Clouva-Molyvdas, M. S. Forbes, F. R. Alleva, and T. Balazs
6-Mercaptopurine Treatment Affects the Membrane Potentials of Rat Skeletal Muscle Fibers
Toxicology and Industrial Health, January 1, 1986; 2(2): 81 - 97.
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 J. Biol. Chem.Home page
C. M. B. Lopes, N. Zilberberg, and S. A. N. Goldstein
Block of Kcnk3 by Protons. EVIDENCE THAT 2-P-DOMAIN POTASSIUM CHANNEL SUBUNITS FUNCTION AS HOMODIMERS
J. Biol. Chem., June 29, 2001; 276(27): 24449 - 24452.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
C. M. B. Lopes, P. G. Gallagher, M. E. Buck, M. H. Butler, and S. A. N. Goldstein
Proton Block and Voltage Gating Are Potassium-dependent in the Cardiac Leak Channel Kcnk3
J. Biol. Chem., May 26, 2000; 275(22): 16969 - 16978.
[Abstract] [Full Text] [PDF]


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