The Journal of General Physiology
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The Journal of General Physiology, Vol 52, 532-549, Copyright © 1968 by The Rockefeller University Press

ARTICLE

The Effect of Calcium Depletion upon the Tension-Independent Component of Cardiac Heat Production

C. L. Gibbs 1 and P. Vaughan 1

1 From the Physiology Department, Monash University, Clayton, Victoria, Australia 3168

Rabbit papillary muscle has been exposed to calcium concentrations ranging from 2.5 mM to zero. Its mechanical and electrical activity has been monitored and its heat production measured using a myothermic technique. Calcium depletion decreased the magnitude of the tension-independent heat per contraction from a mean of 0.45 mcal/g muscle to 0.31 mcal/g muscle at room temperature (18° to 22°C). Calcium-chelating agents did not abolish action potential conduction under the experimental conditions used but they further reduced the magnitude of the tension-independent heat. Raising the temperature from room level to 32°C decreased the tension-independent heat from a mean of 0.52 to a mean of 0.24 mcal/g muscle. Calcium depletion at 32°C further decreased this heat and it was calculated that the energy now liberated in activating the muscle was about 2% of the total energy normally liberated in the working heart. The results are interpreted in terms of current biochemical and myothermic data.

Submitted on February 19, 1968


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