The Journal of General Physiology
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The Journal of General Physiology, Vol 54, 675-689, Copyright © 1969 by The Rockefeller University Press

ARTICLE

Regulation of Liver Tyrosine Aminotransferase by Endogenous Factors in the Mouse

Caleb E. Finch 1, Harris S. Huberman 1, and Alfred E. Mirsky 1

1 From The Rockefeller University, New York 10021

The levels of mouse liver tyrosine aminotransferase (TAT) are shown to increase rapidly and transiently during and after various challenges (e.g., exposure to cold or shaking) to the homeostatic machinery of the fasted mouse. The increase of TAT is dependent on gene activity. Recent feeding and adrenalectomy are shown to inhibit the induction of TAT during the challenge of cold.

Submitted on June 9, 1969


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