The Journal of General Physiology
Sign up for e-mail content alerts
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 816K)
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JGP
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Costantin, L. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Costantin, L. L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
The Journal of General Physiology, Vol 55, 703-715, Copyright © 1970 by The Rockefeller University Press

ARTICLE

The Role of Sodium Current in the Radial Spread of Contraction in Frog Muscle Fibers

L. L. Costantin 1

1 From the Department of Physiology, College of Physicians and Surgeons, Columbia University, New York 10032

The membrane potential of isolated muscle fibers was controlled with a two-electrode voltage clamp, and the radial extent of contraction elicited by depolarizing pulses of increasing magnitude was observed microscopically. Depolarizations of the fiber surface only 1–2 mv greater than the contraction threshold produced shortening throughout the entire cross-section of the muscle fiber. The radial spread of contraction was less effective in fibers exposed to tetrodotoxin or to a bathing medium with a greatly reduced sodium concentration. The results provide evidence that depolarization of a muscle fiber produces an increase in sodium conductance in the T tubule membrane and that the resultant sodium current contributes to the spread of depolarization along the T system.

Submitted on December 10, 1969


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
B. P. Head, H. H. Patel, D. M. Roth, N. C. Lai, I. R. Niesman, M. G. Farquhar, and P. A. Insel
G-protein-coupled Receptor Signaling Components Localize in Both Sarcolemmal and Intracellular Caveolin-3-associated Microdomains in Adult Cardiac Myocytes
J. Biol. Chem., September 2, 2005; 280(35): 31036 - 31044.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
T. CLAUSEN
Na+-K+ Pump Regulation and Skeletal Muscle Contractility
Physiol Rev, October 1, 2003; 83(4): 1269 - 1324.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G S Posterino, G D Lamb, and D G Stephenson
Twitch and tetanic force responses and longitudinal propagation of action potentials in skinned skeletal muscle fibres of the rat
J. Physiol., August 15, 2000; 527(1): 131 - 137.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. Soeller and M. B. Cannell
Examination of the Transverse Tubular System in Living Cardiac Rat Myocytes by 2-Photon Microscopy and Digital Image–Processing Techniques
Circ. Res., February 19, 1999; 84(3): 266 - 275.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
L. D. Peachey
Electrical Events in the T-System of Frog Skeletal Muscle
Cold Spring Harb Symp Quant Biol, January 1, 1973; 37(0): 479 - 487.
[Abstract] [PDF]


  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents