The Journal of General Physiology
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The Journal of General Physiology, Vol 55, 703-715, Copyright © 1970 by The Rockefeller University Press

ARTICLE

The Role of Sodium Current in the Radial Spread of Contraction in Frog Muscle Fibers

L. L. Costantin 1

1 From the Department of Physiology, College of Physicians and Surgeons, Columbia University, New York 10032

The membrane potential of isolated muscle fibers was controlled with a two-electrode voltage clamp, and the radial extent of contraction elicited by depolarizing pulses of increasing magnitude was observed microscopically. Depolarizations of the fiber surface only 1–2 mv greater than the contraction threshold produced shortening throughout the entire cross-section of the muscle fiber. The radial spread of contraction was less effective in fibers exposed to tetrodotoxin or to a bathing medium with a greatly reduced sodium concentration. The results provide evidence that depolarization of a muscle fiber produces an increase in sodium conductance in the T tubule membrane and that the resultant sodium current contributes to the spread of depolarization along the T system.

Submitted on December 10, 1969


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