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The Journal of General Physiology, Vol 58, 634-649, Copyright © 1971 by The Rockefeller University Press

ARTICLE

Temperature Adaptation of Active Sodium-Potassium Transport and of Passive Permeability in Erythrocytes of Ground Squirrels

S. L. Kimzey 1 and J. S. Willis 1

1 From the Department of Physiology and Biophysics, University of Illinois, Urbana, Illinois 61801.

Dr. Kimzey's present address is the Preventive Medicine Division, National Aeronautics and Space Administration Manned Spacraft Center, Houston, Texas.

Unidirectional active and passive fluxes of 42K and 24Na were measured in red blood cells of ground squirrels (hibernators) and guinea pigs (nonhibernators). As temperature is lowered, "active" (ouabain-sensitive) K influx and Na efflux were more greatly diminished in guinea pig cells than in those of ground squirrels. The fraction of total K influx which is ouabain sensitive in red blood cells of ground squirrels was virtually constant at all temperatures, whereas it decreased abruptly in guinea pig cells as temperature was lowered. All the passive fluxes (i.e., Na influx, K efflux, and ouabain-insensitive K influx and Na efflux) decreased logarithmically with decrease in temperature in both species, but in ground squirrels the temperature dependence (Q10 2.5–3.0) was greater than in guinea pig (Q10 1.6–1.9). Thus, red blood cells of ground squirrel are able to resist loss of K and gain of Na at low temperature both because of relatively greater Na-K transport (than in cells of nonhibernators) and because of reduced passive leakage of ions.

Submitted on October 7, 1970


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