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Data are presented showing that the course of decline of egg production with age in the domestic fowl from the time laying begins up to and including 8 years follows an exponential law, that is, each year's egg production is a constant percentage of the preceding year's production (88 per cent in the group of fowl studied). Since the exponential law is the same as the law of monomolecular change in chemistry, and since the course of egg production with age may be taken as an index of the course of senescence of organs, or tissues limiting egg production, it is suggested that this exponential law of egg production substantiates the idea that senescence is a physicochemical process the course of which is limited by a chemical reaction. It is shown that the exhaustion of the oocytes is not likely to be the factor limiting the course of egg production.
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  R. E. Frisch Population, food intake, and fertility. There is historical evidence for a direct effect of nutrition on reproductive ability. Science, January 6, 1978; 199(4324): 22 - 30. [PDF]
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