The Journal of General Physiology
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 968K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JGP
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lännergren, J.
Right arrow Articles by Noth, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lännergren, J.
Right arrow Articles by Noth, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
The Journal of General Physiology, Vol 61, 158-175, Copyright © 1973 by The Rockefeller University Press

ARTICLE

Tension in Isolated Frog Muscle Fibers Induced by Hypertonic Solutions

J. Lännergren 1 and J. Noth 1

1 From the Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden.

Dr. Noth's present address is Physiologisches Institut II, Universität Düsseldorf, Germany.

The effect of hypertonic solutions on the tension of isolated twitch muscle fibers of the frog has been investigated. Increased tonicity up to about 1.7 times normal (1.7 T) caused a very small, graded, maintained tension increase. Above about 1.7 T a large, transient contracture response was superimposed on the small tension. The contracture response was graded with tonicity and reached a maximum at 2.5 T of 108 ± 25 mN·mm2 a third of the maximum tetanic tension in isotonic solution. Contracture tension developed with a delay which decreased with increased tonicity. The contracture threshold was lower and the delay shorter in small fibers than in large. Contractures were obtained equally well in depolarized as in polarized fibers. They were completely suppressed by 0.1–0.5 mM tetracaine. The possible mechanism responsible for the tension-inducing effect of hypertonic solutions is discussed in terms of the close similarity between the properties of these contractures and those caused by caffeine, and it is suggested that the effect is due to a release of calcium from internal stores.

Submitted on July 17, 1972


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Physiol.Home page
S. Chawla, J. N Skepper, A. R Hockaday, and C. L-H Huang
Calcium waves induced by hypertonic solutions in intact frog skeletal muscle fibres
J. Physiol., October 15, 2001; 536(2): 351 - 359.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J Gulati and A Babu
Tonicity effects on intact single muscle fibers: relation between force and cell volume
Science, February 26, 1982; 215(4536): 1109 - 1112.
[Abstract] [PDF]


  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents