|
|
|
|
|
|
|
||
The Journal of General Physiology, Vol 76, 175-211, Copyright © 1980 by The Rockefeller University Press
ARTICLES |
JE Zengel and KL Magleby
Endplate potentials (EPP) were recorded from the frog sartorius neuromuscular junction under conditions of low quantal content to study the effect of Ba2+, Sr2+, and Ca2+ on the changes in evoked transmitter release that occur during and after repetitive stimulation. The addition of 0.1-1 mM Ba2+ or Sr2+ to the Ca2+-containing bathing solution, or the replacement of Ca2+ with 0.8-1.4 mM Sr2+, led to a greater increase in EPP amplitudes during and immediately after repetitive stimulation. These changes in release were analyzed in terms of the four apparent components of increased transmitter release that have previously been distinguished on the basis of their kinetic properties. The Ba2+-induced increase in EPP amplitudes was associated with an increase in the magnitude but not the time constant of decay of augmentation. Ba2+ had little effect on potentiation or the first and second components of facilitation. The Sr2+-induced increase in EPP amplitudes was associated with an increase in the magnitude and the time constant of decay of the second component of facilitation. Sr2+ had little effect on potentiation, augmentation, or the first component of facilitation. The selective effects of Ba2+ on augmentation and of Sr2+ on the second component of facilitation were reversible and could be obtained in the presence of the other ion. The addition of 0.1-0.3 mM Ca2+ to the bathing solution had little effect on potentiation, augmentation, or the two components of facilitation. These results provide pharmacological support for the proposal that there are four different components of increased transmitter release associated with repetitive stimulation and suggest that the underlying factors in the nerve terminal that give rise to these components can act somewhat independently of one another.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Facebook 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  S. M. Young Jr. Proteolysis of SNARE proteins alters facilitation and depression in a specific way PNAS, February 15, 2005; 102(7): 2614 - 2619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Kalkstein and K. L. Magleby Augmentation Increases Vesicular Release Probability in the Presence of Masking Depression at the Frog Neuromuscular Junction J. Neurosci., December 15, 2004; 24(50): 11391 - 11403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-K. Ng, X. Lu, and E. S Levitan Physical mobilization of secretory vesicles facilitates neuropeptide release by nerve growth factor-differentiated PC12 Cells J. Physiol., July 15, 2002; 542(2): 395 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Fitzpatrick, G. Akopian, and J. P. Walsh Short-Term Plasticity at Inhibitory Synapses in Rat Striatum and Its Effects on Striatal Output J Neurophysiol, May 1, 2001; 85(5): 2088 - 2099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Xu-Friedman and W. G. Regehr Probing Fundamental Aspects of Synaptic Transmission with Strontium J. Neurosci., June 15, 2000; 20(12): 4414 - 4422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. Atluri and W. G. Regehr Delayed Release of Neurotransmitter from Cerebellar Granule Cells J. Neurosci., October 15, 1998; 18(20): 8214 - 8227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Behrends and G. ten Bruggencate Changes in Quantal Size Distributions Upon Experimental Variations in the Probability of Release at Striatal Inhibitory Synapses J Neurophysiol, June 1, 1998; 79(6): 2999 - 3011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vyshedskiy and J.-W. Lin Change of Transmitter Release Kinetics During Facilitation Revealed by Prolonged Test Pulses at the Inhibitor of the Crayfish Opener Muscle J Neurophysiol, October 1, 1997; 78(4): 1791 - 1799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Fischer, R. S. Zucker, and T. J. Carew Activity-Dependent Potentiation of Synaptic Transmission From L30 Inhibitory Interneurons of Aplysia Depends on Residual Presynaptic Ca2+ But Not on Postsynaptic Ca2+ J Neurophysiol, October 1, 1997; 78(4): 2061 - 2071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vyshedskiy and J.-W. Lin Activation and Detection of Facilitation as Studied by Presynaptic Voltage Control at the Inhibitor of the Crayfish Opener Muscle J Neurophysiol, May 1, 1997; 77(5): 2300 - 2315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Bolshakov and S. Siegelbaum Regulation of hippocampal transmitter release during development and long-term potentiation Science, September 22, 1995; 269(5231): 1730 - 1734. [Abstract] [PDF]
|
|
|
|
|
|
Kelso SR and T. Brown Differential conditioning of associative synaptic enhancement in hippocampal brain slices Science, April 4, 1986; 232(4746): 85 - 87. [Abstract] [PDF]
|
|
|
|
|
|
T. Brown and D. McAfee Long-term synaptic potentiation in the superior cervical ganglion Science, March 12, 1982; 215(4538): 1411 - 1413. [Abstract] [PDF]
|
|
|
|
