|
|
|
|
|
|
|
||
The Journal of General Physiology, Vol 86, 135-165, Copyright © 1985 by The Rockefeller University Press
ARTICLES |
M Mahler
In frog sartorius muscle, after a tetanus at 20 degrees C, during which an impulse-like increase occurs in the rate of ATP hydrolysis, the rate of O2 consumption (QO2) reaches a peak relatively quickly and then declines monoexponentially, with a time constant not dependent on the tetanus duration (tau = 2.6 min in Rana pipiens and 2.1 min in Rana temporaria). To a good approximation, these kinetics are those of a first-order impulse response, and the scheme of reactions that couple O2 consumption to extramitochondrial ATP hydrolysis thus behaves as a first-order system. It is first deduced and then demonstrated directly that while QO2(t) is monoexponential, it changes in parallel with the levels of creatine and phosphorylcreatine, with proportionality constants +/- 1/tau p, where p is the P/O2 ratio in vivo. From this, it is further deduced that the mitochondrial creatine kinase (CK) reaction is pseudo-first order in vivo. The relationship between [creatine] and QO2 predicted by published models of the control of respiration is markedly different from that actually observed. As shown here, the first-order kinetics of QO2 are consistent with the hypothesis that respiration is rate-limited by the mitochondrial CK reaction; this has as a corollary the "creatine shuttle" hypothesis.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Facebook 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  B. J. Whipp Point: The kinetics of oxygen uptake during muscular exercise do manifest time-delayed phases J Appl Physiol, November 1, 2009; 107(5): 1663 - 1665. [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Jones, D. P. Wilkerson, and J. Fulford Influence of dietary creatine supplementation on muscle phosphocreatine kinetics during knee-extensor exercise in humans Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1078 - R1087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Kemp Physiological implications of linear kinetics of mitochondrial respiration in vitro Am J Physiol Cell Physiol, September 1, 2008; 295(3): C844 - C846. [Full Text] [PDF]
|
|
|
|
|
|
A. R. Barker, J. R. Welsman, J. Fulford, D. Welford, and N. Armstrong Muscle phosphocreatine kinetics in children and adults at the onset and offset of moderate-intensity exercise J Appl Physiol, August 1, 2008; 105(2): 446 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Lador, E. Tam, M. Azabji Kenfack, M. Cautero, C. Moia, D. R. Morel, C. Capelli, and G. Ferretti Phase I dynamics of cardiac output, systemic O2 delivery, and lung O2 uptake at exercise onset in men in acute normobaric hypoxia Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R624 - R632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Jones, D. P. Wilkerson, and J. Fulford Muscle [phosphocreatine] dynamics following the onset of exercise in humans: the influence of baseline work-rate J. Physiol., February 1, 2008; 586(3): 889 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Glancy, T. Barstow, and W. T. Willis Linear relation between time constant of oxygen uptake kinetics, total creatine, and mitochondrial content in vitro Am J Physiol Cell Physiol, January 1, 2008; 294(1): C79 - C87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Jones, D. P. Wilkerson, N. J. Berger, and J. Fulford Influence of endurance training on muscle [PCr] kinetics during high-intensity exercise Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R392 - R401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Baker, D. J. Krause, R. A. Howlett, and R. T. Hepple Nitric oxide synthase inhibition reduces O2 cost of force development and spares high-energy phosphates following contractions in pump-perfused rat hindlimb muscles Exp Physiol, May 1, 2006; 91(3): 581 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Lador, M. Azabji Kenfack, C. Moia, M. Cautero, D. R. Morel, C. Capelli, and G. Ferretti Simultaneous determination of the kinetics of cardiac output, systemic O2 delivery, and lung O2 uptake at exercise onset in men Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R1071 - R1079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Kindig, B. Walsh, R. A. Howlett, C. M. Stary, and M. C. Hogan Relationship between intracellular PO2 recovery kinetics and fatigability in isolated single frog myocytes J Appl Physiol, June 1, 2005; 98(6): 2316 - 2319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Kindig, R. A. Howlett, and M. C. Hogan Effect of contractile duration on intracellular PO2 kinetics in Xenopus single skeletal myocytes J Appl Physiol, May 1, 2005; 98(5): 1639 - 1645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Kindig, R. A. Howlett, C. M. Stary, B. Walsh, and M. C. Hogan Effects of acute creatine kinase inhibition on metabolism and tension development in isolated single myocytes J Appl Physiol, February 1, 2005; 98(2): 541 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Kindig, C. M. Stary, and M. C. Hogan Effect of dissociating cytosolic calcium and metabolic rate on intracellular PO2 kinetics in single frog myocytes J. Physiol., January 15, 2005; 562(2): 527 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Haseler, C. A. Kindig, R. S. Richardson, and M. C. Hogan The role of oxygen in determining phosphocreatine onset kinetics in exercising humans J. Physiol., August 1, 2004; 558(3): 985 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Smith, S. J. Montain, G. P. Zientara, and R. A. Fielding Use of phosphocreatine kinetics to determine the influence of creatine on muscle mitochondrial respiration: an in vivo 31P-MRS study of oral creatine ingestion J Appl Physiol, June 1, 2004; 96(6): 2288 - 2292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fukuba, Y. Ohe, A. Miura, A. Kitano, M. Endo, H. Sato, M. Miyachi, S. Koga, and O. Fukuda Dissociation between the time courses of femoral artery blood flow and pulmonary VO2 during repeated bouts of heavy knee extension exercise in humans Exp Physiol, May 1, 2004; 89(3): 243 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Jones, D. P. Wilkerson, S. Wilmshurst, and I. T. Campbell Influence of L-NAME on pulmonary O2 uptake kinetics during heavy-intensity cycle exercise J Appl Physiol, March 1, 2004; 96(3): 1033 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Endo, S. Tauchi, N. Hayashi, S. Koga, H. B. Rossiter, and Y. Fukuba Facial cooling-induced bradycardia does not slow pulmonary V.O2 kinetics at the onset of high-intensity exercise J Appl Physiol, October 1, 2003; 95(4): 1623 - 1631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Grassi, S. Pogliaghi, S. Rampichini, V. Quaresima, M. Ferrari, C. Marconi, and P. Cerretelli Muscle oxygenation and pulmonary gas exchange kinetics during cycling exercise on-transitions in humans J Appl Physiol, July 1, 2003; 95(1): 149 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J Kemp, M. Roussel, D. Bendahan, Y. L. Fur, and P. J Cozzone Interrelations of ATP synthesis and proton handling in ischaemically exercising human forearm muscle studied by 31P magnetic resonance spectroscopy J. Physiol., September 15, 2001; 535(3): 901 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M C Steiner and M D L Morgan Enhancing physical performance in chronic obstructive pulmonary disease Thorax, January 1, 2001; 56(1): 73 - 77. [Full Text]
|
|
|
|
 |
|
 K. McCully, D. Mancini, and S. Levine Nuclear Magnetic Resonance Spectroscopy: Its Role in Providing Valuable Insight Into Diverse Clinical Problems Chest, November 1, 1999; 116(5): 1434 - 1441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H B Rossiter, S A Ward, V L Doyle, F A Howe, J R Griffiths, and B J Whipp Inferences from pulmonary O2 uptake with respect to intramuscular [phosphocreatine] kinetics during moderate exercise in humans J. Physiol., August 1, 1999; 518(3): 921 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Smith, S. J. Montain, R. P. Matott, G. P. Zientara, F. A. Jolesz, and R. A. Fielding Effects of creatine supplementation on the energy cost of muscle contraction: a 31P-MRS study J Appl Physiol, July 1, 1999; 87(1): 116 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Haseler, M. C. Hogan, and R. S. Richardson Skeletal muscle phosphocreatine recovery in exercise-trained humans is dependent on O2 availability J Appl Physiol, June 1, 1999; 86(6): 2013 - 2018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Hogan, R. S. Richardson, and L. J. Haseler Human muscle performance and PCr hydrolysis with varied inspired oxygen fractions: a 31P-MRS study J Appl Physiol, April 1, 1999; 86(4): 1367 - 1373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Smith, S. J. Montain, R. P. Matott, G. P. Zientara, F. A. Jolesz, and R. A. Fielding Creatine supplementation and age influence muscle metabolism during exercise J Appl Physiol, October 1, 1998; 85(4): 1349 - 1356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Grassi, L. B. Gladden, M. Samaja, C. M. Stary, and M. C. Hogan Faster adjustment of O2 delivery does not affect VO2 on-kinetics in isolated in situ canine muscle J Appl Physiol, October 1, 1998; 85(4): 1394 - 1403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Grassi, L. B. Gladden, C. M. Stary, P. D. Wagner, and M. C. Hogan Peripheral O2 diffusion does not affect VO2 on-kinetics in isolated in situ canine muscle J Appl Physiol, October 1, 1998; 85(4): 1404 - 1412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Haseler, R. S. Richardson, J. S. Videen, and M. C. Hogan Phosphocreatine hydrolysis during submaximal exercise: the effect of FIO2 J Appl Physiol, October 1, 1998; 85(4): 1457 - 1463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Hogan, L. B. Gladden, B. Grassi, C. M. Stary, and M. Samaja Bioenergetics of contracting skeletal muscle after partial reduction of blood flow J Appl Physiol, June 1, 1998; 84(6): 1882 - 1888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Koga, T. Shiojiri, N. Kondo, and T. J. Barstow Effect of increased muscle temperature on oxygen uptake kinetics during exercise J Appl Physiol, October 1, 1997; 83(4): 1333 - 1338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Nevill, D. A. Jones, D. McIntyre, G. C. Bogdanis, and M. E. Nevill A model for phosphocreatine resynthesis J Appl Physiol, January 1, 1997; 82(1): 329 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-F. Toussaint, K. K. Kwong, F. M'Kparu, R. M. Weisskoff, P. J. Laraia, and H. L. Kantor Interrelationship of oxidative metabolism and local perfusion demonstrated by NMR in human skeletal muscle J Appl Physiol, November 1, 1996; 81(5): 2221 - 2228. [Abstract] [Full Text] [PDF]
|
|
|
|
