The Journal of General Physiology
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The Journal of General Physiology, Vol 9, 333-339, Copyright © 1926 by The Rockefeller University Press

ARTICLE

THE DISSOCIATION CONSTANTS OF RACEMIC PROLINE AND CERTAIN RELATED COMPOUNDS

C. M. McCay 1 and Carl L. A. Schmidt 1

1 From the Division of Biochemistry and Pharmacology of the University of California Medical School, Berkeley.

1. It has been experimentally shown that breaking of the pyrrolidine ring of proline by nitrous acid is not a factor of sufficient magnitude to account for the amino nitrogen which is usually found in proline preparations.

2. A method for the preparation of racemic proline is described. The product was found to be free from amino nitrogen.

3. The dissociation constants of racemic proline and of certain structurally related compounds were determined.

 Accepted on October 21, 1925


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