|
|
|
|
|
|
|
||
The Journal of General Physiology, Vol 91, 641-657, Copyright © 1988 by The Rockefeller University Press
ARTICLES |
DS Krafte and RS Kass
Department of Physiology, University of Rochester, New York 14642.
We have investigated the effects of H ions on (L-type) Ca channel current in isolated ventricular cells. We find that the current amplitude is enhanced in solutions that are alkaline relative to pH 7.4 and reduced in solutions acidic to this pH. We measured pH0-induced shifts in channel gating and analyzed our results in terms of surface potential theory. The shifts are well described by changes in surface potential caused by the binding of H ions to negative charges on the cell surface. The theory predicts a pK of 5.8 for this binding. Gating shifts alone cannot explain all of our observations on modulation of current amplitude. Our results suggest that an additional mechanism contributes to modification of the current amplitude.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Facebook 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Jian, R. Barhoumi, M. L. Ko, and G. Y.-P. Ko Inhibitory Effect of Somatostatin-14 on L-Type Voltage-Gated Calcium Channels in Cultured Cone Photoreceptors Requires Intracellular Calcium J Neurophysiol, September 1, 2009; 102(3): 1801 - 1810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rocher, A. I. Caceres, L. Almaraz, and C. Gonzalez EPAC signalling pathways are involved in low PO2 chemoreception in carotid body chemoreceptor cells J. Physiol., August 15, 2009; 587(16): 4015 - 4027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-M. Du and R. D. Nathan Simulated ischemia enhances L-type calcium current in pacemaker cells isolated from the rabbit sinoatrial node Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2986 - H2994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Palmer Modulation of Ca2+-activated K+ currents and Ca2+-dependent action potentials by exocytosis in goldfish bipolar cell terminals J. Physiol., May 1, 2006; 572(3): 747 - 762. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Vessey, A. K. Stratis, B. A. Daniels, N. Da Silva, M. G. Jonz, M. R. Lalonde, W. H. Baldridge, and S. Barnes Proton-Mediated Feedback Inhibition of Presynaptic Calcium Channels at the Cone Photoreceptor Synapse J. Neurosci., April 20, 2005; 25(16): 4108 - 4117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hirasawa and A. Kaneko pH Changes in the Invaginating Synaptic Cleft Mediate Feedback from Horizontal Cells to Cone Photoreceptors by Modulating Ca2+ Channels J. Gen. Physiol., November 24, 2003; 122(6): 657 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Colecraft, D. L. Brody, and D. T. Yue G-Protein Inhibition of N- and P/Q-Type Calcium Channels: Distinctive Elementary Mechanisms and Their Functional Impact J. Neurosci., February 15, 2001; 21(4): 1137 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sun, J.-S. Fan, J. W Clark, and P. T Palade A model of the L-type Ca2+ channel in rat ventricular myocytes: ion selectivity and inactivation mechanisms J. Physiol., November 15, 2000; 529(1): 139 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Marrannes and E. De Prins Site of Action of Lubeluzole on Voltage-Sensitive Ca2+ Channels in Isolated Dorsal Root Ganglion Cells of the Rat: Influence of pH J. Pharmacol. Exp. Ther., November 1, 2000; 295(2): 531 - 545. [Abstract] [Full Text]
|
|
|
|
|
|
S. V. Smirnov, G. A. Knock, A. E. Belevych, and P. I. Aaronson Mechanism of effect of extracellular pH on L-type Ca2+ channel currents in human mesenteric arterial cells Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H76 - H85. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Brody and D. T. Yue Release-Independent Short-Term Synaptic Depression in Cultured Hippocampal Neurons J. Neurosci., April 1, 2000; 20(7): 2480 - 2494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Morrill and R. MacKinnon Isolation of a Single Carboxyl-Carboxylate Proton Binding Site in the Pore of a Cyclic Nucleotide-Gated Channel J. Gen. Physiol., July 1, 1999; 114(1): 71 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B Michaelidis, E Rofalikou, and M. Grieshaber The effects of hypercapnia on force and rate of contraction and intracellular pH of perfused ventricles from the land snail Helix lucorum (L.) J. Exp. Biol., January 11, 1999; 202(21): 2993 - 3001. [Abstract] [PDF]
|
|
|
|
|
|
M. Stengl, E. Carmeliet, K. Mubagwa, and W. Flameng Modulation of transient outward current by extracellular protons and Cd2+ in rat and human ventricular myocytes J. Physiol., September 15, 1998; 511(3): 827 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Santi, T. Santos, A. Hernandez-Cruz, and A. Darszon Properties of a Novel pH-dependent Ca2+ Permeation Pathway Present in Male Germ Cells with Possible Roles in Spermatogenesis and Mature Sperm Function J. Gen. Physiol., July 1, 1998; 112(1): 33 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-H. Chen and R. W. Tsien Aspartate Substitutions Establish the Concerted Action of P-region Glutamates in Repeats I and III in Forming the Protonation Site of L-type Ca2+ Channels J. Biol. Chem., November 28, 1997; 272(48): 30002 - 30008. [Abstract] [Full Text] [PDF]
|
|
|
|
