|
|
|
|
|
|
|
||
The Journal of General Physiology, Vol 94, 911-935, Copyright © 1989 by The Rockefeller University Press
ARTICLES |
JN Weiss and ST Lamp
Department of Medicine, University of California, School of Medicine, Los Angeles 90024.
The ability of glycolysis, oxidative phosphorylation, the creatine kinase system, and exogenous ATP to suppress ATP-sensitive K+ channels and prevent cell shortening were compared in patch-clamped single guinea pig ventricular myocytes. In cell-attached patches on myocytes permeabilized at one end with saponin, ATP-sensitive K+ channels were activated by removing ATP from the bath, and could be closed equally well by exogenous ATP or substrates for endogenous ATP production by glycolysis (with the mitochondrial inhibitor FCCP present), mitochondrial oxidative phosphorylation, or the creatine kinase system. In the presence of an exogenous ATP-consuming system, however, glycolytic substrates (with FCCP present) were superior to substrates for either oxidative phosphorylation or the creatine kinase system at suppressing ATP-sensitive K+ channels. All three groups of substrates were equally effective at preventing cell shortening. In 6 of 38 excised inside-out membrane patches, ATP-sensitive K+ channels activated by removing ATP from the bath were suppressed by a complete set of substrates for the ATP-producing steps of glycolysis but not by individual glycolytic substrates, which is consistent with the presence of key glycolytic enzymes located near the channels in these patches. Under whole-cell voltage-clamp conditions, inclusion of 15 mM ATP in the patch electrode solution dialyzing the interior of the cell did not prevent activation of the ATP-sensitive K+ current under control conditions or during exposure to complete metabolic inhibition. In isolated arterially perfused rabbit interventricular septa, selective inhibition of glycolysis caused an immediate increase in 42K+ efflux rate, which was prevented by 100 microM glyburide, a known blocker of ATP-sensitive K+ channels. These observations suggest that key glycolytic enzymes are associated with cardiac. ATP-sensitive K+ channels and under conditions in which intracellular competition for ATP is high (e.g., in beating heart) that act as a preferential source of ATP for these channels.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Facebook 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. N. Jameel, X. Wang, M. H. J. Eijgelshoven, A. Mansoor, and J. Zhang Transmural distribution of metabolic abnormalities and glycolytic activity during dobutamine-induced demand ischemia Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2680 - H2686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Aromolaran, A. V. Zima, and L. A. Blatter Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells Am J Physiol Cell Physiol, July 1, 2007; 293(1): C106 - C118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Ma, J. Berg, and G. Yellen Ketogenic Diet Metabolites Reduce Firing in Central Neurons by Opening KATP Channels J. Neurosci., April 4, 2007; 27(14): 3618 - 3625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Jackson and S. A. Thayer Mitochondrial Modulation of Ca2+-Induced Ca2+-Release in Rat Sensory Neurons J Neurophysiol, September 1, 2006; 96(3): 1093 - 1104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. O. Reger, M. F. Barbe, M. Amin, B. F. Renna, L. A. Hewston, S. M. MacDonnell, S. R. Houser, and J. R. Libonati Myocardial hypoperfusion/reperfusion tolerance with exercise training in hypertension J Appl Physiol, February 1, 2006; 100(2): 541 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. E MacDonald, J. W Joseph, and P. Rorsman Glucose-sensing mechanisms in pancreatic {beta}-cells Phil Trans R Soc B, December 29, 2005; 360(1464): 2211 - 2225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Libonati, Z. V. Kendrick, and S. R. Houser Sprint training improves postischemic, left ventricular diastolic performance J Appl Physiol, December 1, 2005; 99(6): 2121 - 2127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Dhar-Chowdhury, M. D. Harrell, S. Y. Han, D. Jankowska, L. Parachuru, A. Morrissey, S. Srivastava, W. Liu, B. Malester, H. Yoshida, et al. The Glycolytic Enzymes, Glyceraldehyde-3-phosphate Dehydrogenase, Triose-phosphate Isomerase, and Pyruvate Kinase Are Components of the KATP Channel Macromolecular Complex and Regulate Its Function J. Biol. Chem., November 18, 2005; 280(46): 38464 - 38470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. C. Stanley, F. A. Recchia, and G. D. Lopaschuk Myocardial Substrate Metabolism in the Normal and Failing Heart Physiol Rev, July 1, 2005; 85(3): 1093 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kockskamper, A. V. Zima, and L. A. Blatter Modulation of sarcoplasmic reticulum Ca2+ release by glycolysis in cat atrial myocytes J. Physiol., May 1, 2005; 564(3): 697 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhou, J. E. Salem, G. M. Saidel, W. C. Stanley, and M. E. Cabrera Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemia Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2400 - H2411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. D'Avanzo, H. C. Cho, I. Tolokh, R. Pekhletski, I. Tolokh, C. Gray, S. Goldman, and P. H. Backx Conduction through the Inward Rectifier Potassium Channel, Kir2.1, Is Increased by Negatively Charged Extracellular Residues J. Gen. Physiol., April 25, 2005; 125(5): 493 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Gosmanov, Z. Fan, X. Mi, E. G. Schneider, and D. B. Thomason ATP-sensitive potassium channels mediate hyperosmotic stimulation of NKCC in slow-twitch muscle Am J Physiol Cell Physiol, March 1, 2004; 286(3): C586 - C595. [Abstract] [Full Text]
|
|
|
|
|
|
C.-H. Goh, K.-H. Jung, S. K. Roberts, M. R. McAinsh, A. M. Hetherington, Y.-i. Park, K. Suh, G. An, and H. G. Nam Mitochondria Provide the Main Source of Cytosolic ATP for Activation of Outward-rectifying K+ Channels in Mesophyll Protoplast of Chlorophyll-deficient Mutant Rice (OsCHLH) Seedlings J. Biol. Chem., February 20, 2004; 279(8): 6874 - 6882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vallejo and C. D. Hardin Metabolic organization in vascular smooth muscle: distribution and localization of caveolin-1 and phosphofructokinase Am J Physiol Cell Physiol, January 1, 2004; 286(1): C43 - C54. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Opie Preconditioning and metabolic anti-ischaemic agents Eur. Heart J., October 2, 2003; 24(20): 1854 - 1856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, H. Han, J. Wang, H. Wang, B. Yang, and Z. Wang Impairment of Human Ether-a-Go-Go-related Gene (HERG) K+ Channel Function by Hypoglycemia and Hyperglycemia. SIMILAR PHENOTYPES BUT DIFFERENT MECHANISMS J. Biol. Chem., March 14, 2003; 278(12): 10417 - 10426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A Blatter, J. Kockskamper, K. A Sheehan, A. V Zima, J. Huser, and S. L Lipsius Local calcium gradients during excitation-contraction coupling and alternans in atrial myocytes J. Physiol., January 1, 2003; 546(1): 19 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kockskamper and L. A Blatter Subcellular Ca2+ alternans represents a novel mechanism for the generation of arrhythmogenic Ca2+ waves in cat atrial myocytes J. Physiol., November 15, 2002; 545(1): 65 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Gavete, M. Agote, M. A. Martin, C. Alvarez, and F. Escriva Effects of Chronic Undernutrition on Glucose Uptake and Glucose Transporter Proteins in Rat Heart Endocrinology, November 1, 2002; 143(11): 4295 - 4303. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Knopp, S. Thierfelder, B. Doepner, and K. Benndorf Mitochondria are the main ATP source for a cytosolic pool controlling the activity of ATP-sensitive K+ channels in mouse cardiac myocytes Cardiovasc Res, November 1, 2001; 52(2): 236 - 245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. Jew and R. L. Moore Glibenclamide improves postischemic recovery of myocardial contractile function in trained and sedentary rats J Appl Physiol, October 1, 2001; 91(4): 1545 - 1554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Van Emous, C. L. A. M. Vleggeert-Lankamp, M. G. J. Nederhoff, T. J. C. Ruigrok, and C. J. A. Van Echteld Postischemic Na+-K+-ATPase reactivation is delayed in the absence of glycolytic ATP in isolated rat hearts Am J Physiol Heart Circ Physiol, May 1, 2001; 280(5): H2189 - H2195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sasaki, T. Sato, E. Marban, and B. O'Rourke ATP consumption by uncoupled mitochondria activates sarcolemmal KATP channels in cardiac myocytes Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1882 - H1888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Belke, T. S. Larsen, E. M. Gibbs, and D. L. Severson Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice Am J Physiol Endocrinol Metab, November 1, 2000; 279(5): E1104 - E1113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. M. Sejersted and G. Sjogaard Dynamics and Consequences of Potassium Shifts in Skeletal Muscle and Heart During Exercise Physiol Rev, October 1, 2000; 80(4): 1411 - 1481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Huser, Y. G. Wang, K. A Sheehan, F. Cifuentes, S. L Lipsius, and L. A Blatter Functional coupling between glycolysis and excitation--contraction coupling underlies alternans in cat heart cells J. Physiol., May 1, 2000; 524(3): 795 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. de Jonge and J. W. de Jong Ischemic preconditioning and glucose metabolism during low-flow ischemia: Role of the adenosine A1 receptor Cardiovasc Res, September 1, 1999; 43(4): 909 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Carmeliet Cardiac Ionic Currents and Acute Ischemia: From Channels to Arrhythmias Physiol Rev, July 1, 1999; 79(3): 917 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pesquero, T. Roig, J. Sanchez, and J. Bermudez Na+-K+ pump and metabolic activities of trout erythrocytes during anoxia Am J Physiol Cell Physiol, July 1, 1999; 277(1): C29 - C34. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Paternostro, D. Pagano, T. Gnecchi-Ruscone, R. S Bonser, and P. G Camici Insulin resistance in patients with cardiac hypertrophy Cardiovasc Res, April 1, 1999; 42(1): 246 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Knopp, S. Thierfelder, R. Koopmann, C. Biskup, T. Bohle, and K. Benndorf Anoxia generates rapid and massive opening of KATP channels in ventricular cardiac myocytes Cardiovasc Res, March 1, 1999; 41(3): 629 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O Gryshchenko, I. Fischer, M Dittrich, S Viatchenko-Karpinski, J Soest, M. Bohm-Pinger, P Igelmund, B. Fleischmann, and J Hescheler Role of ATP-dependent K(+) channels in the electrical excitability of early embryonic stem cell-derived cardiomyocytes J. Cell Sci., January 9, 1999; 112(17): 2903 - 2912. [Abstract] [PDF]
|
|
|
|
|
|
W. P. Dubinsky, O. Mayorga-Wark, and S. G. Schultz Colocalization of glycolytic enzyme activity and KATP channels in basolateral membrane of Necturus enterocytes Am J Physiol Cell Physiol, December 1, 1998; 275(6): C1653 - C1659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Erdemli, Y. Z. Xu, and K. Krnjevic Potassium Conductance Causing Hyperpolarization of CA1 Hippocampal Neurons During Hypoxia J Neurophysiol, November 1, 1998; 80(5): 2378 - 2390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shimoni, P. E. Light, and R. J. French Altered ATP sensitivity of ATP-dependent K+ channels in diabetic rat hearts Am J Physiol Endocrinol Metab, October 1, 1998; 275(4): E568 - E576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Hisatome, T. Morisaki, H. Kamma, T. Sugama, H. Morisaki, A. Ohtahara, and E. W. Holmes Control of AMP deaminase 1 binding to myosin heavy chain Am J Physiol Cell Physiol, September 1, 1998; 275(3): C870 - C881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A Losito, R. G Tsushima, R. J Diaz, G. J Wilson, and P. H Backx Preferential regulation of rabbit cardiac L-type Ca2+ current by glycolytic derived ATP via a direct allosteric pathway J. Physiol., August 15, 1998; 511(1): 67 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. P. Dzeja and A. Terzic Phosphotransfer reactions in the regulation of ATP-sensitive K+ channels FASEB J, May 1, 1998; 12(7): 523 - 529. [Abstract] [Full Text]
|
|
|
|
|
|
X W Niu and R W Meech The effect of polyamines on KATP channels in guinea-pig ventricular myocytes J. Physiol., April 15, 1998; 508(2): 401 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Silver and M. Erecinska Glucose-Induced Intracellular Ion Changes in Sugar-Sensitive Hypothalamic Neurons J Neurophysiol, April 1, 1998; 79(4): 1733 - 1745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Dizon, D. Burkhoff, J. Tauskela, J. Whang, P. Cannon, and J. Katz Metabolic inhibition in the perfused rat heart: evidence for glycolytic requirement for normal sodium homeostasis Am J Physiol Heart Circ Physiol, April 1, 1998; 274(4): H1082 - H1089. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Wu, C. Aoki, A. Elste, A. A. Rogalski-Wilk, and P. Siekevitz The synthesis of ATP by glycolytic enzymes in the postsynaptic density and the effect of endogenously generated nitric oxide PNAS, November 25, 1997; 94(24): 13273 - 13278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tsuchiya, M. Horie, M. Watanuki, C. A. Albrecht, K. Obayashi, H. Fujiwara, and S. Sasayama Functional Compartmentalization of ATP Is Involved in Angiotensin II–Mediated Closure of Cardiac ATP-Sensitive K+ Channels Circulation, November 4, 1997; 96(9): 3129 - 3135. [Abstract] [Full Text]
|
|
|
|
|
|
S. Shigematsu and M. Arita Anoxia-induced activation of ATP-sensitive K+ channels in guinea pig ventricular cells and its modulation by glycolysis Cardiovasc Res, August 1, 1997; 35(2): 273 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Shaw and Y. Rudy Electrophysiologic Effects of Acute Myocardial Ischemia: A Mechanistic Investigation of Action Potential Conduction and Conduction Failure Circ. Res., January 1, 1997; 80(1): 124 - 138. [Abstract] [Full Text]
|
|
|
|
|
|
M. Watanuki, M. Horie, K. Tsuchiya, K. Obayashi, and S. Sasayama Endothelin-1 inhibition of cardiac ATP-sensitive K+ channels via pertussis-toxin-sensitive G-proteins Cardiovasc Res, January 1, 1997; 33(1): 123 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Y. Xu, J. L. Zweier, and L. C. Becker Functional Coupling Between Glycolysis and Sarcoplasmic Reticulum Ca2+ Transport Circ. Res., July 1, 1995; 77(1): 88 - 97. [Abstract] [Full Text]
|
|
|
|
|
|
A. Bhatnagar Electrophysiological Effects of 4-Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, on Isolated Rat Ventricular Myocytes Circ. Res., February 1, 1995; 76(2): 293 - 304. [Abstract] [Full Text]
|
|
|
|
|
|
K. N. Jew and R. L. Moore Exercise training alters an anoxia-induced, glibenclamide-sensitive current in rat ventricular cardiocytes J Appl Physiol, April 1, 2002; 92(4): 1473 - 1479. [Abstract] [Full Text] [PDF]
|
|
|
|
