The Journal of General Physiology, Vol 95, 1103-1122, Copyright © 1990 by The Rockefeller University Press

ARTICLES

Biphasic Ca2+ dependence of inositol 1,4,5-trisphosphate-induced Ca release in smooth muscle cells of the guinea pig taenia caeci

M Iino
Department of Pharmacology, Faculty of Medicine, University of Tokyo, Japan.

Ca2+ dependence of the inositol 1,4,5-trisphosphate (IP3)-induced Ca release was studied in saponin-skinned smooth muscle fiber bundles of the guinea pig taenia caeci at 20-22 degrees C. Ca release from the skinned fiber bundles was monitored by microfluorometry of fura-2. Fiber bundles were first treated with 30 microM ryanodine for 120 s in the presence of 45 mM caffeine to lock open the Ca-induced Ca release channels which are present in approximately 40% of the Ca store of the smooth muscle cells of the taenia. The Ca store with the Ca-induced Ca release mechanism was functionally removed by this treatment, but the rest of the store, which was devoid of the ryanodine-sensitive Ca release mechanism, remained intact. The Ca2+ dependence of the IP3- induced Ca release mechanism was, therefore, studied independently of the Ca-induced Ca release. The rate of IP3-induced Ca release was enhanced by Ca2+ between 0 and 300 nM, but further increase in the Ca2+ concentration also exerted an inhibitory effect. Thus, the rate of IP3- induced Ca release was about the same in the absence of Ca2+ and at 3 microM Ca2+, and was about six times faster at 300 nM Ca2+. Hydrolysis of IP3 within the skinned fiber bundles was not responsible for these effects, because essentially the same effects were observed with or without Mg2+, an absolute requirement of the IP3 phosphatase activity. Ca2+, therefore, is likely to affect the gating mechanism and/or affinity for the ligand of the IP3-induced Ca release mechanism. The biphasic effect of Ca2+ on the IP3-induced Ca release is expected to form a positive feedback loop in the IP3-induced Ca mobilization below 300 nM Ca2+, and a negative feedback loop above 300 nM Ca2+.
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				M. Arimitsu, M. Mitsui-Saito, K. Sato, H. Ozaki, Y. Koga, and H. Karaki Mechanism of Relaxant Effect of Clonidine in Isolated Bovine Tracheal Smooth Muscle J. Pharmacol. Exp. Ther., August 1, 1998; 286(2): 681 - 687. [Abstract] [Full Text]

				T. M. Moore, P. M. Chetham, J. J. Kelly, and T. Stevens Signal transduction and regulation of lung endothelial cell permeability. Interaction between calcium and cAMP Am J Physiol Lung Cell Mol Physiol, August 1, 1998; 275(2): L203 - L222. [Abstract] [Full Text] [PDF]

				J.-M. Hyvelin, C. Guibert, R. Marthan, and J.-P. Savineau Cellular mechanisms and role of endothelin-1-induced calcium oscillations in pulmonary arterial myocytes Am J Physiol Lung Cell Mol Physiol, August 1, 1998; 275(2): L269 - L282. [Abstract] [Full Text] [PDF]

				H. KURIYAMA, K. KITAMURA, T. ITOH, and R. INOUE Physiological Features of Visceral Smooth Muscle Cells, With Special Reference to Receptors and Ion Channels Physiol Rev, July 1, 1998; 78(3): 811 - 920. [Abstract] [Full Text] [PDF]

				V. D. Lupu, E. Kaznacheyeva, U. M. Krishna, J. R. Falck, and I. Bezprozvanny Functional Coupling of Phosphatidylinositol 4,5-Bisphosphate to Inositol 1,4,5-Trisphosphate Receptor J. Biol. Chem., June 5, 1998; 273(23): 14067 - 14070. [Abstract] [Full Text] [PDF]

				E. Kaznacheyeva, V. D. Lupu, and I. Bezprozvanny Single-Channel Properties of Inositol (1,4,5)-Trisphosphate Receptor Heterologously Expressed in HEK-293 Cells J. Gen. Physiol., June 1, 1998; 111(6): 847 - 856. [Abstract] [Full Text] [PDF]

				X.-P. Sun, N. Callamaras, J. S Marchant, and I. Parker A continuum of InsP3-mediated elementary Ca2+ signalling events in Xenopus oocytes J. Physiol., May 15, 1998; 509(1): 67 - 80. [Abstract] [Full Text] [PDF]

				N. Callamaras, J. S Marchant, X.-P. Sun, and I. Parker Activation and co-ordination of InsP3-mediated elementary Ca2+ events during global Ca2+ signals in Xenopus oocytes J. Physiol., May 15, 1998; 509(1): 81 - 91. [Abstract] [Full Text] [PDF]

				L. Missiaen, J. B. Parys, I. Sienaert, K. Maes, K. Kunzelmann, M. Takahashi, K. Tanzawa, and H. De Smedt Functional Properties of the Type-3 InsP3 Receptor in 16HBE14o- Bronchial Mucosal Cells J. Biol. Chem., April 10, 1998; 273(15): 8983 - 8986. [Abstract] [Full Text] [PDF]

				T. Capiod ATP-activated cation currents in single guinea-pig hepatocytes J. Physiol., March 15, 1998; 507(3): 795 - 805. [Abstract] [Full Text] [PDF]

				T. Toyofuku, M. Yabuki, K. Otsu, T. Kuzuya, M. Hori, and M. Tada Intercellular Calcium Signaling via Gap Junction in Connexin-43-transfected Cells J. Biol. Chem., January 16, 1998; 273(3): 1519 - 1528. [Abstract] [Full Text] [PDF]

				K. Hirose, S. Kadowaki, and M. Iino Allosteric regulation by cytoplasmic Ca2+ and IP3 of the gating of IP3 receptors in permeabilized guinea-pig vascular smooth muscle cells J. Physiol., January 15, 1998; 506(2): 407 - 414. [Abstract] [Full Text] [PDF]

				E. J. Kaftan, B. E. Ehrlich, and J. Watras Inositol 1,4,5-Trisphosphate (InsP3) and Calcium Interact to Increase the Dynamic Range of InsP3 Receptor-dependent Calcium Signaling J. Gen. Physiol., November 1, 1997; 110(5): 529 - 538. [Abstract] [Full Text] [PDF]

				M. J. Barrero, M. Montero, and J. Alvarez Dynamics of [Ca2+] in the Endoplasmic Reticulum and Cytoplasm of Intact HeLa Cells. A COMPARATIVE STUDY J. Biol. Chem., October 31, 1997; 272(44): 27694 - 27699. [Abstract] [Full Text] [PDF]

				I. Sienaert, L. Missiaen, H. De Smedt, J. B. Parys, H. Sipma, and R. Casteels Molecular and Functional Evidence for Multiple Ca2+-binding Domains in the Type 1 Inositol 1,4,5-Trisphosphate Receptor J. Biol. Chem., October 10, 1997; 272(41): 25899 - 25906. [Abstract] [Full Text] [PDF]

				D. Ogden and T. Capiod Regulation of Ca2+ Release by InsP3 in Single Guinea Pig Hepatocytes and Rat Purkinje Neurons J. Gen. Physiol., June 1, 1997; 109(6): 741 - 756. [Abstract] [Full Text] [PDF]

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