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Correction

Page 391.
Table IV referred to previous data from Chen et al. (1996) concerning mutations in domain IV of the sodium channel. However, the numbering system for mutations in domain IV used by Chen et al. (1996) differed from that used in this paper. Therefore, two mutants were labeled incorrectly. Mutant 4R1Q should have been termed 4R0Q, and mutant 4R3Q should have been termed 4R2Q. The corrected table is reprinted below.
Table IV Summary of Charge-neutralizing Mutation Effects on Activation

Mutant v1/2 shift* zm change (e0)* mV 1R1Q +3.3 –0.6 1R1Q –2.0 0.0 1R2Q –1.0 +0.4 1R2Q –8.0 –1.8|| 1R3Q +4.7176 –1.7176 1R3Q +12.0 –1.5|| 1K4Q +18.5176 –1.2176 1K4Q +19.0 –0.9|| 2R1Q +13.3176 –1.2176 2R2Q +4.4176 –1.1176 2R3Q +0.4176 –1.6176 2K4Q +14.9176 –0.7 2K5Q +10.0 0.0 3K1Q –10.4176 –0.5 3R2Q –0.3 +0.4 3R3Q +5.9176 –2.1176 3R4Q –18.1176 +0.3 4R0Q +2.3 –1.6176 4R2Q +3.6176 –0.5 4R2Q +8.6176 –1.6176 4R4Q +0.4 +0.9

^* v_1/2 and z_m are the half-maximal voltage and gating valence of activation. Data from Stühmer et al. (1989) did not include an assessment of statistical significance.  

Data from Chen et al. (1996).  

Data from Stühmer et al. (1989).  

^|| The values for z_m from Stühmer et al. (1989) were multiplied by three for comparison because those values were based on three identical gating charges (m³).  

¹⁷⁶ Values statistically significant, with a probability <0.05 resulting from random variation.  

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This Article Full Text (PDF, 86K) Alert me when this article is cited Services Email this article Similar articles in this journal Alert me to new content in the JGP Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kontis Articles by Goldin., A.L. Search for Related Content PubMed Articles by Kontis, Articles by Goldin., A.L. Social Bookmarking                            What's this?