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[View Larger Version of this Image]
Figure S1. Effect of series resistance (Rs) on simulated kinetics of inactivation. The simulations were done using script file cain.par. Typical experimental value for Rs is ∼10 MΩ, which includes resistance of the pipette and of the intracellular access to the membrane. (A) Simulated ionic currents for Rs = 1 MΩ, γ = 100. (B) Simulated ionic currents for Rs = 20 MΩ, γ = 100. (C) Peak current-voltage relationships for currents in A and B. (D) Rates of the best fits by the sum of an exponential and a constant to the decay phase of currents in A and B.
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