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Figure S2. Effect of local Ca²⁺ accumulation on simulated kinetics of inactivation. The simulations were done using script file cain2.par. Here, the inactivation-block coupling factor γ in conducting states is a function of the single-channel current: γ = γ₀ + εi_s.ch. Rs was 5 MΩ throughout. (A) Simulated ionic currents for γ₀ = 50, ε = 0. (B) Simulated ionic currents for γ₀ = 50, ε = 200. (C) Peak current-voltage relationships for currents in A and B. (D) Rates of the best fits by the sum of an exponential and a constant to the decay phase of currents in A and B.

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