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Index of Online Supplemental Material for
J. Gen. Physiol. 10.1085/jgp.200810007
Hernandez et al.
• Figure S1 The triple KRR-EEE mutation also reduces the apparent affinity of Kv7.2 channels for diC8-PI(3,4)P2.
• Figure S2 The triple KRR-EEE mutation only slightly shifts the voltage dependence of activation of Kv7.2 channels.
• Figure S3 Charge reversal of other basic residues, or swaps of nonconserved residues between Kv7.2 and Kv7.3, in the helix A-B linker have no effect.
• Figure S4 Overexpression of PI(4)5-kinase affects macroscopic current amplitudes to the degree corresponding with the maximal Po and apparent PIP2 affinity of the channel.
• Tables S1-S3 (PDF)
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