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Correction

Page 403.
Table IV referred to previous data from Chen et al. (1996) concerning mutations in domain IV of the sodium channel. However, the numbering system for mutations in domain IV used by Chen et al. (1996) differed from that used in this paper. Therefore, two mutants were labeled incorrectly. Mutant 4R1Q should have been termed 4R0Q, and mutant 4R3Q should have been termed 4R2Q. The corrected table is reprinted below.
Table IV Summary of Charge Neutralization Mutation Effects on Fast Inactivation

Channel v1/2 shift* ah change* mV 1R1Q  –0.8 –0.2 1R1Q  –5.0 –0.8 1R2Q  –5.1|| –1.0|| 1R2Q  –6.0 –0.5 1R3Q  –5.8 –1.1|| 1R3Q  +6.0 +1.4 1K4Q  –3.7|| –0.4|| 1K4Q  –6.0 +0.9 2R1Q  +8.2|| –0.4 2R2Q  –8.1|| –0.8|| 2R3Q  –9.6|| –1.1|| 2K4Q  –5.7|| –0.6|| 2K5Q  –9.0 –0.8 3K1Q –21.0|| –0.8|| 3R2Q  –8.5|| –0.9|| 3R3Q –10.6|| –0.6 3R4Q  –3.2||   0.0 4R0Q  +4.7|| –2.0|| 4R2Q  –0.6 –0.5|| 4R2Q –57.5|| –2.6|| 4R4Q  +0.2 +0.3

^* v_1/2 and a_h are the half-maximal voltage and slope factor for fast inactivation. Data from Stühmer et al. (1989) did not include an assessment of statistical significance.  

Data from Chen et al. (1966).  

Data from Stühmer et al. (1989). These data were acquired using a 100-ms prepulse, whereas all other data were acquired using a 500-ms prepulse.  

^|| Values statistically significant, with a probability <0.05 resulting from random variation.  

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This Article Full Text (PDF, 86K) Alert me when this article is cited Services Email this article Similar articles in this journal Alert me to new content in the JGP Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kontis Articles by Goldin., A.L. Search for Related Content PubMed Articles by Kontis, Articles by Goldin., A.L. Social Bookmarking                            What's this?