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Correction

Page 577

Due to an editorial error, rate constant units in the first column, last paragraph, were printed incorrectly. The affected paragraph appears (corrected) here:

For the simulations, the following parameters were used: channel opening of 600 ms with a 1.2-pA Ca²⁺ current; initial free intracellular Ca²⁺ concentration of 100 nM; total endogenous stationary buffer concentration of 230 µM and total fluo-3 concentration of 50 µM; an on-rate of 80 (µM · s)^–1 for fluo-3 and 100 (µM · s)^–1 for the stationary buffer; an off-rate of 90 s^–1 for fluo-3 and 100 s^–1 for the stationary buffer (yielding a K_d of 1.13 µM for fluo-3 and 1 µM for the stationary buffer); a diffusion constant of 2.5 x 10^–6 cm²/s for Ca²⁺ and 2.2 x 10^–7 cm² /s for free and Ca²⁺-bound fluo-3. The effects of plasma membrane pumps and leaks were negligible and no other intracellular activity (e.g., Ca²⁺-induced Ca²⁺ release, Ca²⁺ uptake) was included. Diffusion, rate and dissociation constants, and the concentration of stationary buffer are from Smith et al. (1998) or Kargacin and Fay (1991).

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This Article Full Text (PDF, 15K) Alert me when this article is cited Services Email this article Similar articles in this journal Alert me to new content in the JGP Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                            What's this?