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Correction for Muroi and Chanda, J. Gen. Physiol. 133 (1) 1-15.
Published online
doi:10.1085/jgp.200810103032009c
The Journal of General Physiology, Vol. 133, No. 4, 459-
The Rockefeller University Press, 0022-1295 $30.00
© Muroi et al.
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CORRECTION

 Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel

Yukiko Muroi and Baron Chanda

Copyright © 2009 by the Rockefeller University Press

Volume 133, No. 1, January 5, 2009. Pages 1–15.

In the original article, the wrong set of traces was inadvertently copied and placed in Fig. 3 A. The correct Fig. 3 is shown below.


Figure 1
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  		Figure 3. The effect of lidocaine on the voltage-dependent fluorescence of labeled sodium channel domains. (A) Time-dependent fluorescence changes from TMR-labeled S216C, S660C, L1115C, and S1436C channels before (left) and after (right) a 10-mM lidocaine application. Inset shows the pulse protocol. Each trace was obtained by averaging 10 trials with an interval of 1 s between pulses. The y axis in the scale bar represents percent fluorescence change ({Delta}F/F). L1115C fluorescence traces were inverted for comparison. (B) Steady-state F-V relationship of TMR-labeled S216C, S660C, L1115C, and S1436C channels before (black) and after (red) a 10-mM lidocaine application. Circles represent the means ± SE of at least five independent experiments, whereas the lines represent the best fits of the averaged data to a single Boltzmann function.

 

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This Article
Right arrow Full Text (PDF, 1083K)
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