Computational Biology

Computational Biology

Interpretation of spectroscopic data using molecular simulations for the secondary active transporter BetP
Vanessa Leone, Izabela Waclawska, Katharina Kossmann, Caroline Koshy, Monika Sharma, Thomas F. Prisner, Christine Ziegler, Burkhard Endeward, Lucy R. Forrest

The Journal of General Physiology Feb 2019, jgp.201812111; DOI: 10.1085/jgp.201812111
Reinterpretation of the substrate specificity of the voltage-sensing phosphatase during dimerization
Martin Kruse, Susy C. Kohout, Bertil Hille

The Journal of General Physiology Feb 2019, 151 (2) 258-263; DOI: 10.1085/jgp.201812260
Facilitation of I_Kr current by some hERG channel blockers suppresses early afterdepolarizations
Kazuharu Furutani, Kunichika Tsumoto, I-Shan Chen, Kenichiro Handa, Yuko Yamakawa, Jon T. Sack, Yoshihisa Kurachi

The Journal of General Physiology Feb 2019, 151 (2) 214-230; DOI: 10.1085/jgp.201812192
The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening
Juan M. Valdez Capuccino, Payal Chatterjee, Isaac E. García, Wesley M. Botello-Smith, Han Zhang, Andrew L. Harris, Yun Luo, Jorge E. Contreras

The Journal of General Physiology Dec 2018, jgp.201812219; DOI: 10.1085/jgp.201812219
The tarantula toxin GxTx detains K⁺ channel gating charges in their resting conformation
Drew C. Tilley, Juan M. Angueyra, Kenneth S. Eum, Heesoo Kim, Luke H. Chao, Anthony W. Peng, Jon T. Sack

The Journal of General Physiology Nov 2018, jgp.201812213; DOI: 10.1085/jgp.201812213
Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states
Farooq A. Kiani, William Lehman, Stefan Fischer, Michael J. Rynkiewicz

The Journal of General Physiology Jan 2019, 151 (1) 4-8; DOI: 10.1085/jgp.201812188
A bilobal model of Ca²⁺-dependent inactivation to probe the physiology of L-type Ca²⁺ channels
Worawan B. Limpitikul, Joseph L. Greenstein, David T. Yue, Ivy E. Dick, Raimond L. Winslow

The Journal of General Physiology Dec 2018, 150 (12) 1688-1701; DOI: 10.1085/jgp.201812115
Kinetic properties of persistent Na⁺ current orchestrate oscillatory bursting in respiratory neurons
Tadashi Yamanishi, Hidehiko Koizumi, Marco A. Navarro, Lorin S. Milescu, Jeffrey C. Smith

The Journal of General Physiology Nov 2018, 150 (11) 1523-1540; DOI: 10.1085/jgp.201812100
A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine
Marina A. Kasimova, Aysenur Torun Yazici, Yevgen Yudin, Daniele Granata, Michael L. Klein, Tibor Rohacs, Vincenzo Carnevale

The Journal of General Physiology Nov 2018, 150 (11) 1554-1566; DOI: 10.1085/jgp.201812124
Determining the molecular basis of voltage sensitivity in membrane proteins
Marina A. Kasimova, Erik Lindahl, Lucie Delemotte

The Journal of General Physiology Oct 2018, 150 (10) 1444-1458; DOI: 10.1085/jgp.201812086

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