Computational Biology

Computational Biology

The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening
Juan M. Valdez Capuccino, Payal Chatterjee, Isaac E. García, Wesley M. Botello-Smith, Han Zhang, Andrew L. Harris, Yun Luo, Jorge E. Contreras

The Journal of General Physiology Dec 2018, jgp.201812219; DOI: 10.1085/jgp.201812219
A bilobal model of Ca²⁺-dependent inactivation to probe the physiology of L-type Ca²⁺ channels
Worawan B. Limpitikul, Joseph L. Greenstein, David T. Yue, Ivy E. Dick, Raimond L. Winslow

The Journal of General Physiology Dec 2018, 150 (12) 1688-1701; DOI: 10.1085/jgp.201812115
Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states
Farooq A. Kiani, William Lehman, Stefan Fischer, Michael J. Rynkiewicz

The Journal of General Physiology Nov 2018, jgp.201812188; DOI: 10.1085/jgp.201812188
The tarantula toxin GxTx detains K⁺ channel gating charges in their resting conformation
Drew C. Tilley, Juan M. Angueyra, Kenneth S. Eum, Heesoo Kim, Luke H. Chao, Anthony W. Peng, Jon T. Sack

The Journal of General Physiology Nov 2018, jgp.201812213; DOI: 10.1085/jgp.201812213
Kinetic properties of persistent Na⁺ current orchestrate oscillatory bursting in respiratory neurons
Tadashi Yamanishi, Hidehiko Koizumi, Marco A. Navarro, Lorin S. Milescu, Jeffrey C. Smith

The Journal of General Physiology Nov 2018, 150 (11) 1523-1540; DOI: 10.1085/jgp.201812100
A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine
Marina A. Kasimova, Aysenur Torun Yazici, Yevgen Yudin, Daniele Granata, Michael L. Klein, Tibor Rohacs, Vincenzo Carnevale

The Journal of General Physiology Nov 2018, 150 (11) 1554-1566; DOI: 10.1085/jgp.201812124
Determining the molecular basis of voltage sensitivity in membrane proteins
Marina A. Kasimova, Erik Lindahl, Lucie Delemotte

The Journal of General Physiology Oct 2018, 150 (10) 1444-1458; DOI: 10.1085/jgp.201812086
A two-step docking site model predicting different short-term synaptic plasticity patterns
Camila Pulido, Alain Marty

The Journal of General Physiology Aug 2018, 150 (8) 1107-1124; DOI: 10.1085/jgp.201812072
Molecular determination of claudin-15 organization and channel selectivity
Priyanka Samanta, Yitang Wang, Shadi Fuladi, Jinjing Zou, Ye Li, Le Shen, Christopher Weber, Fatemeh Khalili-Araghi

The Journal of General Physiology Jul 2018, 150 (7) 949-968; DOI: 10.1085/jgp.201711868
Mitochondrial ATP synthase dimers spontaneously associate due to a long-range membrane-induced force
Claudio Anselmi, Karen M. Davies, José D. Faraldo-Gómez

The Journal of General Physiology May 2018, 150 (5) 763-770; DOI: 10.1085/jgp.201812033

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