Figure 10 Model of Ca^{2+}-dependent inactivation. Three modes of L-type Ca^{2+} channels are originating from a single deep closed state (*C*_{01}). The top line has no opening: the channel remains silent. The middle and bottom lines end with open states and subsequent Ca^{2+}-dependent inactivated states. The rates (α, β), charges (z), and fractions of the field (δ) that have been used for the fits and simulation are shown in Table I, and they refer to the kinetic transitions as follows: α_{01}, β_{01}, z_{1}, δ_{1}: C_{01 }↔ C_{02}; α_{02}, β_{02}, z_{2}, δ_{2}: C_{02 }↔ C_{03}; α_{03}, β_{03}, z_{3}, δ_{3}: C_{03 }↔ O_{04}; α_{04}, β_{04}: O_{04 }↔ I_{05}, Ca^{2+}-dependent, voltage-independent transition; α_{12}, β_{12}, z_{2}, δ_{2}: C_{12 }↔ C_{13}; α_{13}, β_{13}, z_{3}, δ_{3}: C_{13 }↔ C_{14}; α_{22}, β_{22}, z_{2}, δ_{2}: C_{22 }↔ C_{23}; α_{23}, β_{23}, z_{3}, δ_{3}: C_{23 }↔ O_{24}; α_{24}, β_{24}: O_{24 }↔ I_{25}, Ca^{2+}-dependent, voltage-independent transition; α_{n}, β_{n}: C_{02 }↔ C_{12}, voltage-independent transition; α_{bk}, β_{bk}: C_{02 }↔ C_{22}, voltage-independent transition; α_{b}, β_{b}: C_{03 }↔ C_{23}, voltage-independent transition.