March 2014 | Volume 143, No. 3
- Differential regulation of CaV1.2 channels by cAMP-dependent protein kinase bound to A-kinase anchoring proteins 15 and 79/150
AKAP79/150 and AKAP15 exert functionally antagonistic effects on CaV1.2 channels.
- Divergence of Ca2+ selectivity and equilibrium Ca2+ blockade in a Ca2+ release-activated Ca2+ channel
The Ca2+ selectivity of CRAC channels depends on the kinetics of ion entry and exit as well as the steady-state Ca2+ binding affinity.
- Complex role of STIM1 in the activation of store-independent Orai1/3 channels
Arachidonic acid (AA)-regulated Ca2+ (ARC) currents and leukotriene C4 (LTC4)-regulated Ca2+ (LRC) currents are mediated by the same populations of proteins.
- Mutation of I696 and W697 in the TRP box of vanilloid receptor subtype I modulates allosteric channel activation
Residues I696 and W697 are crucial to coupling between the TRPV1 ligand- and voltage-sensing domains and the channel pore.
- Long α helices projecting from the membrane as the dimer interface in the voltage-gated H+ channel
Continuous helices extending from the transmembrane region to the cytoplasmic region form a dimeric interface to regulate activation of the voltage-gated H+ channel.
- Dynamic coupling of regulated binding sites and cycling myosin heads in striated muscle
Myosim, a computer model of muscle contraction, includes molecular-level effects and incorporates dynamic coupling of myosin heads and binding sites.
Methods and Approaches
- Determination of parameter identifiability in nonlinear biophysical models: A Bayesian approach
A Bayesian approach can be used to determine the reliability of estimated parameters in biophysical models.