April 2014 | Volume 143, No. 4
- Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps
The Na+/K+ pump is a hybrid transporter that can also import protons at physiological K+ and Na+ concentrations.
- Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation
The analgesic α-conotoxin Vc1.1 inhibits Cav2.3 channels through a GABAB receptor–dependent pathway involving c-Src.
- Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons
Ex vivo analyses indicate that spontaneous activity in vestibular neurons depends on resting hair cell mechanotransduction and HCN channels in calyx terminals.
Methods and Approaches
- Sarcomere length nanometry in rat neonatal cardiomyocytes expressed with α-actinin–AcGFP in Z discs
Nanoscale imaging of cultured cardiomyocytes allows the quantitative assessment of changes in the length of single sarcomeres during contractile events.