August 2014 | Volume 144, No. 2
- Disrupted coupling of gating charge displacement to Na+ current activation for DIIS4 mutations in hypokalemic periodic paralysis
Defective coupling between gating charge displacement and channel activation may contribute to reduced muscle excitability in hypokalemic periodic paralysis.
- Tracking S4 movement by gating pore currents in the bacterial sodium channel NaChBac
Comparison of the kinetics and voltage dependence of gating pore current conducted by S4 gating charge mutants supports the sliding-helix model of voltage sensor function and elucidates the pathogenic mechanisms underlying periodic paralysis syndromes.
- Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR
Disease-associated mutation of charged amino acids in extracellular loop 1 of CFTR may reduce chloride flow by damaging the outer pore architecture.
- The conserved potassium channel filter can have distinct ion binding profiles: Structural analysis of rubidium, cesium, and barium binding in NaK2K
The ion-binding profile in NaK2K is distinct from that in KcsA, even though the selectivity filter has been conserved.