October 2014 | Volume 144, No. 4
- Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity
Chromaffin cells from mice lacking the BK β2 subunit show decreased action potential firing during current injection but an increase in spontaneous burst firing.
- Voltage-dependent regulation of CaV2.2 channels by Gq-coupled receptor is facilitated by membrane-localized β subunit
The pathway through which preferentially GqPCRs inhibit CaV2.2 channels depends on which β subunits are present.
- Structure–activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects
The head and tail regions of 5-nitro-2-(3-phenylpropylamino)benzoate increase CFTR open probability through distinct mechanisms.
- Intersubunit conformational changes mediate epithelial sodium channel gating
Residues forming interfaces between the three ENaC subunits participate in conformational changes required for transition between open and closed states.