November 2014 | Volume 144, No. 5
- Calmodulin enhances ribbon replenishment and shapes filtering of synaptic transmission by cone photoreceptors
Calmodulin promotes vesicle replenishment at photoreceptor ribbon synapses, enabling cones to transmit higher-frequency visual information.
- Altered Ca2+ signaling in skeletal muscle fibers of the R6/2 mouse, a model of Huntington’s disease
A mouse model of Huntington’s disease shows impaired calcium handling in skeletal muscle, potentially contributing to the pathology of the disease.
- Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism
The tremorogenic alkaloid paxilline binds more tightly to closed conformations of the BK channel, stabilizing the closed state.
- A self-consistent approach for determining pairwise interactions that underlie channel activation
Net free-energy measurements can be combined with mutant cycle analysis to determine interaction energies between specific amino acid pairs during channel activation.
- Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels
Gating interaction analysis reveals a cluster of three conserved amino acids that couple structural transitions in the potassium channel voltage sensor to those in the pore.
- Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: A mechanistic study
Sulfonylureas suppress the stimulatory effect of Mg-nucleotides on recombinant β-cell (Kir6.2/SUR1) but not cardiac (Kir6.2/SUR2A) KATP channels.