January 2015 | Volume 145, No. 1
- Mechanism of activation of the prokaryotic channel ELIC by propylamine: A single-channel study
The prokaryotic ligand-gated channel ELIC opens to two open states when maximally activated by the binding of at least two agonist molecules.
- Hydrophobic interaction between contiguous residues in the S6 transmembrane segment acts as a stimuli integration node in the BK channel
Phenylalanine 380 and leucine 377 in the BK channel S6 transmembrane helix of contiguous subunits participate in a hydrophobic interaction in both the closed and open state; this interaction is important in the allosteric coupling between the Ca2+ and voltage sensors and pore domain.