February 2015 | Volume 145, No. 2
- To better serve our community: Introducing new Associate Editors and an expanded Editorial Advisory Board for 2015
We are pleased to welcome several new JGP Associate Editors and Editorial Advisory Board members.
- Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy
Nav1.5 channels bearing voltage-sensor domain mutations associated with atypical cardiac arrhythmias and dilated cardiomyopathy generate gating pore currents.
- Mapping the membrane topography of the TH6–TH7 segment of the diphtheria toxin T-domain channel
Cysteine substitution accessibility analysis suggests that the TH6–TH7 segment forms a constriction in the diphtheria toxin T-domain channel.
Methods and Approaches
- New method for determining total calcium content in tissue applied to skeletal muscle with and without calsequestrin
The concentration of total calcium in a skeletal muscle appears to be correlated with the muscle’s likely force requirements given by the ratio of body weight to muscle weight.
- A surface plasmon resonance approach to monitor toxin interactions with an isolated voltage-gated sodium channel paddle motif
The isolated Nav channel domain IV paddle motif remains susceptible to toxins that inhibit fast inactivation.