April 2015 | Volume 145, No. 4
- Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels
Both the catalytically active and inactive interfacial ATP-binding sites open at least 8 Å during CFTR channel closure.
- Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons
TMEM16A is an essential component of Ca2+-activated Cl− currents in mouse vomeronasal sensory neurons.
- Apparent lack of physical or functional interaction between CaV1.1 and its distal C terminus
The distal C-terminal domain of CaV1.1 is not required for depolarization-induced potentiation of L-type Ca2+ current in skeletal muscle.
- Voltage-dependent gating and gating charge measurements in the Kv1.2 potassium channel
Kv1.2’s gating charge is less than Shaker’s, and the specific contributions of charged S4 residues differ, suggesting that the electric field distribution in the Kv1.2 voltage-sensing domain is different than Shaker’s.