May 2015 | Volume 145, No. 5
- Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations
Decreasing the amplitude of the late component of the cardiac L-type Ca2+ channel current suppresses early afterdepolarizations, thereby decreasing the risk of arrhythmias.
- Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2′-phosphate
ADP-ribose-2′-phosphate acts as a direct agonist of TRPM2, whereas NAD, NAAD, and NAADP do not.
- A combined coarse-grained and all-atom simulation of TRPV1 channel gating and heat activation
Coarse-grained modeling and all-atom molecular dynamics simulation provide insight into the mechanism for heat activation of TRPV1 gating.