July 2015 | Volume 146, No. 1
- The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold
Functional analyses of ELIC raise the intriguing possibility that this bacterial channel may represent a previously unrecognized branch of the superfamily of pentameric ligand-gated ion channels with markedly divergent pore properties.
- Comparative sequence analysis suggests a conserved gating mechanism for TRP channels
Comparative sequence analysis indicates that a common mechanism underlying polymodal gating of TRP channels involves the relaxation of a structural distortion of pore-lining helices.
- Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel
PI(4,5)P2 is required for TRPM3 activity, establishing its role as a crucial cofactor for the entire TRPM channel family.
- Membrane potential and Ca2+ concentration dependence on pressure and vasoactive agents in arterial smooth muscle: A model
A mathematical model incorporating junctional and stretch-activated microdomains and 37 protein components describes the myogenic response in arterial smooth muscle cells.
- Rem uncouples excitation–contraction coupling in adult skeletal muscle fibers
The RGK protein Rem uncouples the voltage sensors of CaV1.1 from RYR1-mediated sarcoplasmic reticulum Ca2+ release via its ability to interact with the auxiliary β1a subunit.
- A marginal band of microtubules transports and organizes mitochondria in retinal bipolar synaptic terminals
A band of microtubules ringing the retinal bipolar cell synaptic terminal may be crucial to supply and anchor the mitochondria required to sustain transmitter release.