September 2015 | Volume 146, No. 3
- Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons
Constitutive and ligand-dependent GHSR1a activity attenuates CaV2 current and hypothalamic GABA release through distinct mechanisms and signaling pathways.
- Integrins mediate mechanical compression–induced endothelium-dependent vasodilation through endothelial nitric oxide pathway
Integrins mediate endothelial NO production and vasodilation in response to the compression of muscle arterioles.
- The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells
Analyses of the Tmc1 Beethoven mouse mutant indicate that hair cell mechanotransducer channel adaptation in mammals is mainly regulated by changes in intracellular Ca2+.
Methods and Approaches
- Glutathione release through connexin hemichannels: Implications for chemical modification of pores permeable to large molecules
The cytosolic reducing agent glutathione can reverse thiol modification of cysteine residues inside the pores of connexins and other channels permeable to large molecules.
- Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide–gated channels
Replacement of a single proline with threonine gives rise to an altered conformation of the Drosophila CNG channel selectivity filter that leads to weak Ca2+ block of monovalent ion current.