October 2015 | Volume 146, No. 4
- Diffusion of myosin light chain kinase on actin: A mechanism to enhance myosin phosphorylation rates in smooth muscle
One-dimensional diffusion of myosin light chain kinase along actin filaments enables the rapid phosphorylation of smooth muscle myosin.
- Na,K-ATPase α2 activity in mammalian skeletal muscle T-tubules is acutely stimulated by extracellular K+
The K+ affinity of the Na,K-ATPase α2 isoform matches its activity to the range of extracellular K+ concentrations in the T-tubules at rest and during contraction, maintaining the excitability of active muscle.
- Reconciling depressed Ca2+ sparks occurrence with enhanced RyR2 activity in failing mice cardiomyocytes
Alterations in the intracellular environment lead to decreased frequency of Ca2+ sparks in a model of heart failure despite enhanced ryanodine receptor activity.
- A novel Ca2+-feedback mechanism extends the operating range of mammalian rods to brighter light
A previously unidentified calcium-dependent mechanism contributes to light adaptation in mammalian rods.
- A chimeric prokaryotic pentameric ligand–gated channel reveals distinct pathways of activation
A chimeric ligand–gated channel is activated by the ligands that activate both parent channels, which gate it through two distinct mechanisms.