November 2015 | Volume 146, No. 5
- Tryptophan 207 is crucial to the unique properties of the human voltage-gated proton channel, hHV1
A conserved tryptophan uniquely present in the voltage-sensing domain of voltage-gated proton channels is surprisingly crucial to four channel-defining properties.
- Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate
PIP2 mediates the bimodal regulation of the EAG family K+ channel ELK1 to produce an overall inhibitory effect.
- Modal affinities of endplate acetylcholine receptors caused by loop C mutations
Modal activity at the nicotinic acetylcholine receptor, in which open channel probability switches reversibly between discrete values, arises from changes in the resting affinity at the agonist site.
- Altered conductance and permeability of Cx40 mutations associated with atrial fibrillation
Alterations in the permeability and conductance of mutant atrial connexins may contribute to reentry arrhythmias.
- A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization
A missense mutation in the pore-forming α subunit of a delayed rectifier Kv channel is associated with epileptic encephalopathy, alters the cation selectivity of voltage-gated currents, and disrupts channel expression and localization.
- Family resemblances: A common fold for some dimeric ion-coupled secondary transporters
The structures of two bacterial antiporters that act as multidrug resistance efflux pumps, MtrF and YdaH, resemble each other and that of the sodium-coupled succinate symporter VcINDY.