December 2015 | Volume 146, No. 6
- Asymmetric protonation of EmrE
The active-site glutamate 14 residues of the homodimeric multidrug transporter EmrE have distinct macroscopic pKa values, raising new questions regarding the coupling of proton import to drug efflux.
- A general mechanism for drug promiscuity: Studies with amiodarone and other antiarrhythmics
Clinically important antiarrhythmic drugs may act by modifying primarily physical properties of the cell membrane.
- Understanding the physiology of the asymptomatic diaphragm of the M1592V hyperkalemic periodic paralysis mouse
When muscles become paralyzed in crises of hyperkalemic periodic paralysis, patients do not stop breathing. Here is why.
- Differential mechanisms of Cantú syndrome–associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel
Mutations that increase the activity of ATP-sensitive potassium channels through either enhanced activation by MgADP or decreased sensitivity to inhibition by ATP can lead to Cantú syndrome.