March 2016 | Volume 147, No. 3
- Regulation of ENaC trafficking in rat kidney
In response to salt depletion, aldosterone drives the movement of Na channel protein from ER through the Golgi to the apical membrane in kidney epithelial cells.
- Retigabine holds KV7 channels open and stabilizes the resting potential
Researchers studied the mechanism by which the anticonvulsant Retigabine enhances the activity of K+ channels and found that the drug stabilizes on open state at resting membrane potentials.
- Multiple cytosolic calcium buffers in posterior pituitary nerve terminals
Researchers have measured the ability of nerve terminals to buffer Ca2+ entering in response to electrical activity to better understand plasticity of hormone release.
- Contributions of protein kinases and β-arrestin to termination of protease-activated receptor 2 signaling
Systematic imaging studies and modeling reveal new details of the regulation of the Gq-coupled GPCR, protease-activated receptor 2, by phosphorylation and β-arrestin.