April 2016 | Volume 147, No. 4
- Transient contractions of urinary bladder smooth muscle are drivers of afferent nerve activity during filling
As the urinary bladder fills, the rate of rise (but not the frequency) of spontaneous contractions of smooth muscle in the bladder wall increases, thereby eliciting increased afferent nerve activity that signals the fullness of the bladder.
- The single transmembrane segment determines the modulatory function of the BK channel auxiliary γ subunit
Researchers identify regions of tissue-specific γ subunits that are responsible for regulating the activity of calcium-activated potassium channels.
Methods and Approaches
- Stabilization of a prokaryotic LAT transporter by random mutagenesis
A fluorescence-based screen was used to analyze 70 LAT transporter mutants and identify variants with improved stability and monodispersity.