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March 2017 | Volume 149, No. 3

News

  • Research News

    • Gating ring strengthens marriage of BK channel voltage sensing to pore opening
      Gating ring strengthens marriage of BK channel voltage sensing to pore opening

      A new JGP study shows that the gating ring helps the voltage-sensing domain open the BK channel’s pore.

      Caitlin Sedwick

Commentary

  • Acting on an impulse (or two): Advantages of high-frequency tetanic onset in skeletal muscle
    Acting on an impulse (or two): Advantages of high-frequency tetanic onset in skeletal muscle

    Moss et al. highlight why high-frequency bursts at the onset of tetany increase force development in fast-twitch skeletal muscle fibers.

    Richard L. Moss, Thomas L. Lynch, Daniel P. Fitzsimons

Reviews

  • Review

    • Fusion pores and their control of neurotransmitter and hormone release
      Fusion pores and their control of neurotransmitter and hormone release

      Chang et al. review fusion pore structure and dynamics and discuss the implications for hormone and neurotransmitter release

      Che-Wei Chang, Chung-Wei Chiang, Meyer B. Jackson

Research Articles

  • Research Articles

    • Doublet stimulation increases Ca<sup>2+</sup> binding to troponin C to ensure rapid force development in skeletal muscle
      Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle

      High-frequency paired stimuli used to initiate a tetanus result in increased force and rate of force development in skeletal muscle. Bakker et al. investigate this mechanism and find that doublet stimulation increases the amount of Ca2+ bound to troponin C, resulting in rapid force development.

      Anthony J. Bakker, Tanya R. Cully, Catherine D. Wingate, Christopher J. Barclay, Bradley S. Launikonis
    • Mechanisms creating transient and sustained photoresponses in mammalian retinal ganglion cells
      Mechanisms creating transient and sustained photoresponses in mammalian retinal ganglion cells

      Visual stimuli of different frequencies are encoded in the retina using transient and sustained responses. Zhao et al. describe the different strategies that are used by four types of retinal ganglion cells to shape photoresponse kinetics.

      Xiwu Zhao, Aaron N. Reifler, Melanie M. Schroeder, Elizabeth R. Jaeckel, Andrew P. Chervenak, Kwoon Y. Wong
    • Electrostatic tuning of the pre- and post-hydrolytic open states in CFTR
      Electrostatic tuning of the pre- and post-hydrolytic open states in CFTR

      Gating of the CFTR channel is coupled to ATP hydrolysis such that two open states can be identified under certain conditions. Zhang and Hwang find that pore-lining mutations differentially affect the permeation properties of these open states and suggest that the internal vestibule expands upon ATP hydrolysis.

      Jingyao Zhang, Tzyh-Chang Hwang
    • Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels
      Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels

      Both cellular depolarization and intracellular Ca2+ can gate open large conductance Ca2+-activated K+ channels. Zhang et al. show that the intracellular gating ring, which forms the Ca2+-sensing machinery of the channel, is also required for activated voltage sensors to effectively gate open the pore.

      Guohui Zhang, Yanyan Geng, Yakang Jin, Jingyi Shi, Kelli McFarland, Karl L. Magleby, Lawrence Salkoff, Jianmin Cui
    • Regulation of Na<sup>+</sup> channel inactivation by the DIII and DIV voltage-sensing domains
      Regulation of Na+ channel inactivation by the DIII and DIV voltage-sensing domains

      Hsu et al. probe voltage-gated Na+ channels that are inactivation deficient with voltage-clamp fluorometry. They find that in the time domain of an action potential, the voltage-sensing domain (VSD) of domain IV regulates fast inactivation onset while the domain III VSD determines its recovery.

      Eric J. Hsu, Wandi Zhu, Angela R. Schubert, Taylor Voelker, Zoltan Varga, Jonathan R. Silva
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The Journal of General Physiology: 149 (3)

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Print ISSN: 0022-1295

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