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October 2018 | Volume 150, No. 10

News

  • Research News

    • Predicting voltage sensing
      Predicting voltage sensing

      New method predicts the molecular basis of membrane proteins’ voltage sensitivity.

      Caitlin Sedwick
  • Essay

    • Influences: Experimenting with multidisciplinary training
      • JGP 100th Anniversary
      Influences: Experimenting with multidisciplinary training

      Cheng recalls the multidisciplinary influence of his trans-Pacific training.

      Heping (Peace) Cheng

Commentaries

  • Commentaries

    • The exquisitely cooperative nature of Orai1 channel activation
      The exquisitely cooperative nature of Orai1 channel activation

      Yeung and Prakriya highlight new research showing that STIM1 must bind to all six Orai1 subunits to effectively activate the channel.

      Priscilla See-Wai Yeung, Murali Prakriya
    • Opening leads to closing: Allosteric crosstalk between the activation and inactivation gates in KcsA
      Opening leads to closing: Allosteric crosstalk between the activation and inactivation gates in KcsA

      Delemotte appraises new computational work revealing that the intracellular activation gate must open for C-type inactivation to occur in K+ channels.

      Lucie Delemotte

Reviews

  • Viewpoint

    • Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors
      Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors

      Burger et al. summarize our mechanistic understanding of allostery in the prototypical GPCR, the muscarinic acetylcholine receptor.

      Wessel A.C. Burger, Patrick M. Sexton, Arthur Christopoulos, David M. Thal

Research Articles

  • Research Articles

    • Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits
      Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits

      The quantitative relation between STIM1 binding to Orai1 and store-operated CRAC channel activation is not well understood. Yen and Lewis find that STIM1 must bind to all six Orai1 subunits to effectively open the channel and generate the high ion selectivity and low conductance seen in native cells.

      Michelle Yen, Richard S. Lewis
    • Phenotypic plasticity in <em>Periplaneta americana</em> photoreceptors
      Phenotypic plasticity in Periplaneta americana photoreceptors

      Neuronal plasticity in adulthood is important for adaptation to different environments. Frolov et al. show that rearing mature Periplaneta americana in prolonged light or dark leads to distinct changes in photoreceptor responses, suggesting remodeling of the light-sensitive membrane.

      Roman V. Frolov, Esa-Ville Immonen, Paulus Saari, Päivi H. Torkkeli, Hongxia Liu, Andrew S. French
    • Determinants of selective ion permeation in the epithelial Na<sup>+</sup> channel
      Determinants of selective ion permeation in the epithelial Na+ channel

      The origin of ion selectivity in epithelial Na+ channels and the closely related acid-sensing ion channels is uncertain. Yang and Palmer show that the site of ion selectivity in epithelial Na+ channels is more extracellular than that proposed for acid-sensing ion channels.

      Lei Yang, Lawrence G. Palmer
    • Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel
      Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel

      C-type inactivation in K+ channels is thought to be a result of constriction of the selectivity filter. By using MD simulations, Li et al. show that rapid constriction occurs within 1–2 s when the intracellular activation gate is fully open, but not when the gate is closed or partially open.

      Jing Li, Jared Ostmeyer, Luis G. Cuello, Eduardo Perozo, Benoît Roux
    • One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels
      One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels

      Retigabine is a widely studied potassium channel activator that is thought to interact with a conserved Trp side chain in the pore domain of Kv7 subunits. Yau et al. demonstrate that drug sensitivity in just one of the four subunits is sufficient for a near-maximal response to retigabine.

      Michael C. Yau, Robin Y. Kim, Caroline K. Wang, Jingru Li, Tarek Ammar, Runying Y. Yang, Stephan A. Pless, Harley T. Kurata
    • Four drug-sensitive subunits are required for maximal effect of a voltage sensor–targeted KCNQ opener
      Four drug-sensitive subunits are required for maximal effect of a voltage sensor–targeted KCNQ opener

      Kv7 potassium channels are strongly activated by a variety of small molecules with diverse mechanisms of action. Wang et al. investigate a compound that targets the voltage-sensing domain, ICA-069673, and demonstrate that four drug-sensitive subunits are required for maximal effect.

      Alice W. Wang, Michael C. Yau, Caroline K. Wang, Nazlee Sharmin, Runying Y. Yang, Stephan A. Pless, Harley T. Kurata
    • Determining the molecular basis of voltage sensitivity in membrane proteins
      Determining the molecular basis of voltage sensitivity in membrane proteins

      The identification of voltage-sensing elements in membrane proteins is challenging due to the diversity of voltage-sensing mechanisms. Kasimova et al. present a computational approach to predict the elements involved in voltage sensing, which they validate using voltage-gated ion channels.

      Marina A. Kasimova, Erik Lindahl, Lucie Delemotte
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The Journal of General Physiology: 150 (10)

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