ON THE COVER
The 2,3-benzodiazepine compound GYKI-52466, a selective non-competitive antagonist of AMPA receptors, binds to the extracellular linkers between agonist binding and channel domains and coordinates channel gating, shifting the pattern from a step-like one to a cooperative one, where the closed channel opens mainly to one of four different open levels observed in control recordings. Top: A channel making transitions between closed and fully open levels in the presence of 10 μM GYKI-52466 (1-kHz filter/20-kHz sampling). Bottom: A portion of the top (box, 7-kHz filter) with color-coded lines that indicate C (black), O1 (red), O2 (blue), O3 (green), and O4 (orange) current levels typically observed in the absence of the antagonist.
See page 156.