Skip to main content

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subject Collections
    • Special Collections
  • Reviews & Opinions
    • Editorials
    • Research News
    • Essays
    • Commentaries
    • Perspectives
    • Milestones in Physiology
    • Reviews
    • Viewpoints
  • Alerts
  • About
    • About JGP
    • History
    • Editors & Staff
    • Permissions & Licensing
    • Advertise
    • Contact Us
    • Privacy Policy
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Publication Fees
    • Author Services
  • Subscriptions
  • Rockefeller University Press
  • JCB
  • JEM
  • JGP
  • LSA

User menu

  • Log in

Search

  • Advanced search
JGP
  • Rockefeller University Press
  • JCB
  • JEM
  • JGP
  • LSA
  • Log in
JGP

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subject Collections
    • Special Collections
  • Reviews & Opinions
    • Editorials
    • Research News
    • Essays
    • Commentaries
    • Perspectives
    • Milestones in Physiology
    • Reviews
    • Viewpoints
  • Alerts
  • About
    • About JGP
    • History
    • Editors & Staff
    • Permissions & Licensing
    • Advertise
    • Contact Us
    • Privacy Policy
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Publication Fees
    • Author Services
  • Subscriptions

February 2019 | Volume 151, No. 2

Cover image

Cover image expansion

ON THE COVER
The 2,3-benzodiazepine compound GYKI-52466, a selective non-competitive antagonist of AMPA receptors, binds to the extracellular linkers between agonist binding and channel domains and coordinates channel gating, shifting the pattern from a step-like one to a cooperative one, where the closed channel opens mainly to one of four different open levels observed in control recordings. Top: A channel making transitions between closed and fully open levels in the presence of 10 μM GYKI-52466 (1-kHz filter/20-kHz sampling). Bottom: A portion of the top (box, 7-kHz filter) with color-coded lines that indicate C (black), O1 (red), O2 (blue), O3 (green), and O4 (orange) current levels typically observed in the absence of the antagonist.
See page 156.

Previous issue
Back to top
Previous issue
The Journal of General Physiology: 151 (2)

In This Issue

  • Cover (PDF)
  • Cover Caption
  • Masthead (PDF)
Alerts
right arrow
Advertisement

Most Read

  • Metformin ameliorates diastolic dysfunction
  • Functional anatomy of CFTR
  • Fluorescence improvement with melanin
  • Ryanodine receptor structure and function
  • "Bitter tasting" via non-taste cells
More...

ARTICLES

  • Current Issue
  • Newest Articles
  • Archive
  • Alerts
  • RSS feeds

FOR AUTHORS

  • Submit a Manuscript
  • Instructions for Authors

ABOUT

  • About JGP
  • Editors & Staff
  • Permissions & Licensing
  • Advertise
  • Feedback
  • Newsroom
  • Privacy Policy

CONNECT WITH JGP

  • Email
  • Facebook
  • Twitter
  • RSS
  • Instagram

Online ISSN: 1540-7748
Print ISSN: 0022-1295

Copyright © 2019 JGP by Rockefeller University Press