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jgp Home » 1958 Archive » 20 July » 41 (6): 1135
Article

THE CALCULATION OF TRANSFER RATES IN TWO COMPARTMENT SYSTEMS NOT IN DYNAMIC EQUILIBRIUM

Eugene Y. Berger, J. Murray Steele
Eugene Y. Berger
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J. Murray Steele
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DOI: 10.1085/jgp.41.6.1135 | Published July 20, 1958
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Abstract

Dynamic equilibrium in a biological system implies that the compartment under study does not change in size during the period of observation. In many biological systems there are, however, net changes with time and this report deals with the mathematical treatment necessary to calculate unequal rates of inflow and outflow.

A method is presented for the calculation of transfer rates in a two compartment system when the rates of flow between these compartments are unequal but constant. Equations were developed to calculate the amount of material transported per unit time derived from measurements of specific activity and compartment size.

The problems of (1) sampling from the pool and (2) the effects of analytical errors on the estimation of rate have been evaluated. An example has been presented in which the derived equations have been applied to a study of the simultaneous passage of sodium into and out of a permanently isolated loop of bowel.

Footnotes

    • Submitted: 26 December 1957
© 1958 Rockefeller University Press
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THE CALCULATION OF TRANSFER RATES IN TWO COMPARTMENT SYSTEMS NOT IN DYNAMIC EQUILIBRIUM
Eugene Y. Berger, J. Murray Steele
The Journal of General Physiology Jul 1958, 41 (6) 1135-1152; DOI: 10.1085/jgp.41.6.1135

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The Journal of General Physiology: 151 (12)

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December 2, 2019
Volume 151, No. 12

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