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jgp Home » 1980 Archive » 1 April » 75 (4): 427
Article

The nonelectrolyte permeability of planar lipid bilayer membranes.

E Orbach, A Finkelstein
E Orbach
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A Finkelstein
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DOI: 10.1085/jgp.75.4.427 | Published April 1, 1980
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Abstract

The permeability of lecithin bilayer membranes to nonelectrolytes is in reasonable agreement with Overton's rule. The is, Pd alpha DKhc, where/Pd is the permeability coefficient of a solute through the bilayer, Khc is its hydrocarbon:water partition coefficient, and D is its diffusion coefficient in bulk hydrocarbon. The partition coefficients are by far the major determinants of the relative magnitudes of the permeability coefficients; the diffusion coefficients make only a minor contribution. We note that the recent emphasis on theoretically calculated intramembranous diffusion coefficients (Dm'S) has diverted attention from the experimentally measurable and physiologically relevant permeability coefficients (Pd'S) and has obscured the simplicity and usefulness of Overton's rule.

© 1980 Rockefeller University Press
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The nonelectrolyte permeability of planar lipid bilayer membranes.
E Orbach, A Finkelstein
The Journal of General Physiology Apr 1980, 75 (4) 427-436; DOI: 10.1085/jgp.75.4.427

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The Journal of General Physiology: 151 (2)

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February 4, 2019
Volume 151, No. 2

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