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COVER PICTURE: Models for strong inward rectification in K+ channels due to block by intracellular amines. Steep voltage dependence of block reflects the movement of charges carried across the transmembrane electrical field primarily by K+ ions, not by the amine itself, as K+ ions and blockers displace each other in the pore. See related article by Guo, D., Y. Ramu, A. Klem, and Z. Lu in this issue, pp. 261-275.)
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