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Cover picture: The transmembrane domain of the bacterial mechanosensitive channel MscS in MD-equilibrated closed (left panel) and open (center) states. In the closed state, the gate (yellow) is dehydrated; in the open state, which is 10 Å wider, the pore is hydrated and conductive. The hydration energy profiles are shown on the right (see article by Anishkin et al., 67–83).
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